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May play a role in vesicle trafficking (By similarity). Zusätzlich bieten wir Ihnen Synaptotagmin Like Protein 1 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
High Expression of secretory leukocyte protease inhibitor is associated with metastasis in colorectal cancer.
SLPI regulation and activity is altered in the nasal mucosa of smokers.
Cdk2 also binds the N-terminal domain of Fbw7-gamma as well as SLP-1.
during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin.
transcriptional activation of JFC1 by the TNFalpha/NF-kappaB pathway is significant in prostate carcinoma cell lines
evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers
Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC.
These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1.
Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
Expression of Rab27B-binding proteinm Sytl1 in pancreatic acinar cells and its involvement in amylase secretion are reported.
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
NADPH oxidase-related, C2 domain-containing protein
, synaptotagmin-like protein 1