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Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. Zusätzlich bieten wir Ihnen Synaptopodin Antikörper (112) und Synaptopodin Kits (41) und viele weitere Produktgruppen zu diesem Protein an.
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The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients.
Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin (zeige ALB Proteine) excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin (zeige ALB Proteine) excretion.
SYNPO variants are involved in AMPA (zeige GRIA3 Proteine) receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.
This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia
Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A (zeige GLA Proteine) mutation.
expression significantly down-regulated in presence of WT1 (zeige WT1 Proteine) R458Q mutation
Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing.
These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA (zeige GRIA3 Proteine)-receptors (AMPA (zeige GRIA3 Proteine)-R) at excitatory synapses. [review]
The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.
Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
synaptopodin-deficient mice lacking the cisternal organelle showed AIS (zeige AR Proteine) shortening in the dark
Results link synaptopodin (SP) with ryanodine receptors, in that ryanodine is able to convert short-term potentiation to long-term potentiation under our testing conditions only in ventral hippocampus, and only in the presence of SP in this region of the hippocampus.
miR-206 was up-regulated in Adriamycin nephropathy mice, which led to severe podocyte injury and inhibited the expression of WT1 and synaptopodin. In vitro, over expression of miR-206 induced WT1 and synaptopodin degradation and actin rearrangement, initiating a catastrophic collapse of the entire podocyte-stabilizing system.
WAVE1 (zeige WASF1 Proteine) phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA (zeige HSPA9 Proteine). WAVE1 (zeige WASF1 Proteine) overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 (zeige WASF1 Proteine) expression is not dependent on synaptopodin expression, and vice versa
synaptopodin has an essential, calcium store-related role in regulating synaptic plasticity in cultured hippocampal neurons
Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development.
Synaptopodin has an important role in homeostatic synaptic plasticity
Together, these results indicate that alpha-actinin (zeige ACTN1 Proteine) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (zeige AR Proteine).
Synpatopodin may play an important role in the changes of PSD-95 and NR1 protein levels and other synaptic alterations that are induced by corticosterone
HGF (zeige HGF Proteine) protects podocytes from a loss of nephrin (zeige NPHS1 Proteine), at least in part, through maintaining synaptopodin in nephritic mice with albuminuria.
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997