Synaptopodin Proteine (SYNPO)

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. Zusätzlich bieten wir Ihnen Synaptopodin Antikörper (114) und Synaptopodin Kits (40) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SYNPO 11346 Q8N3V7
SYNPO 104027  
Ratte SYNPO SYNPO 60324 Q9Z327
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage

SYNPO Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Synaptopodin (SYNPO) Interaktionspartnern

Human Synaptopodin (SYNPO) Interaktionspartner

  1. The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients.

  2. Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion.

  3. SYNPO variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.

  4. This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia

  5. Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A mutation.

  6. expression significantly down-regulated in presence of WT1 R458Q mutation

  7. Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing.

  8. These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA-receptors (AMPA-R) at excitatory synapses. [review]

  9. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.

  10. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.

  11. Heterozygous mutations in the promoters of the ACTN4 and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis.

  12. interaction with tight junction protein MAGI-1

  13. Our data suggest dendritic spine accumulation of SYNPO critically depends on interaction with postsynaptic alpha-actinin and that SYNPO may regulate spine morphology, motility and function via its distinct modes of association with the actin cytoskeleton.

  14. Reduced expression of both synaptopodin and GLEPP1 is associated with poor response to steroid therapy in primary focal segmental glomerulosclerosis.

  15. Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes.

  16. We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia.

  17. Discusses isoforms of mouse Synpo, two of which are consistent with those found in human.

Mouse (Murine) Synaptopodin (SYNPO) Interaktionspartner

  1. synaptopodin-deficient mice lacking the cisternal organelle showed AIS shortening in the dark

  2. Results link synaptopodin (SP) with ryanodine receptors, in that ryanodine is able to convert short-term potentiation to long-term potentiation under our testing conditions only in ventral hippocampus, and only in the presence of SP in this region of the hippocampus.

  3. miR-206 was up-regulated in Adriamycin nephropathy mice, which led to severe podocyte injury and inhibited the expression of WT1 and synaptopodin. In vitro, over expression of miR-206 induced WT1 and synaptopodin degradation and actin rearrangement, initiating a catastrophic collapse of the entire podocyte-stabilizing system.

  4. WAVE1 phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA. WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa

  5. synaptopodin has an essential, calcium store-related role in regulating synaptic plasticity in cultured hippocampal neurons

  6. Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development.

  7. Synaptopodin has an important role in homeostatic synaptic plasticity

  8. Together, these results indicate that alpha-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS.

  9. Synpatopodin may play an important role in the changes of PSD-95 and NR1 protein levels and other synaptic alterations that are induced by corticosterone

  10. HGF protects podocytes from a loss of nephrin, at least in part, through maintaining synaptopodin in nephritic mice with albuminuria.

  11. In this review, hippocampal neurons in SP-knockout mice lack a dendritic spine apparatus and express lower long term potential, probably playing a role in synaptic plasticity and linked mechanistically to synaptic functions.

  12. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.

  13. the distribution pattern of synaptopodin protein depends on the position and orientation of the spine-bearing neurons

  14. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.

  15. Data demonstrate a lamina-specific distribution of Synaptopodin within dendritic segments of identified neurons. Within dendrites, the majority of Synaptopodin-positive puncta were located in spines where they represent spine apparatuses.

  16. We found synaptopodin expression in primary sensory neurons of craniospinal ganglia.

  17. CD2AP, Fyn, and synaptopodin have roles in development of focal segmental glomerulosclerosis in a mouse model

  18. Studies in mice have shown that sFlt-1 may play a role in inducing proteinuria by neutralizing vascular endothelial growth factor (VEGF) and suppressing nephrin and synaptopodin.

  19. Synaptopodin directly binds to IRSp53 and suppresses Cdc42:IRSp53:Mena-initiated filopodia formation by blocking the binding of Cdc42 and Mena to IRSp53.

  20. The result of this study demonstrate that synaptopodin is an essential component of the cisternal organelle of axons and of the dendritic spine apparatus, two organelles that are structurally and molecularly related.

Synaptopodin (SYNPO) Protein Überblick

Protein Überblick

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997

Genbezeichner und Symbole assoziert mit Synaptopodin Proteine (SYNPO)

  • synaptopodin (SYNPO)
  • formin-like protein 5 (LOC100147046)
  • synaptopodin (Synpo)
  • 9030217H17Rik Protein
  • 9130229N11 Protein
  • 9330140I15Rik Protein
  • AW046661 Protein
  • DKFZp459N012 Protein
  • SYNPO Protein

Bezeichner auf Proteinebene für Synaptopodin Proteine (SYNPO)

synaptopodin , synaptopodin-like

471697 Pan troglodytes
100029044 Monodelphis domestica
100147046 Equus caballus
100174064 Pongo abelii
100408223 Callithrix jacchus
100470428 Ailuropoda melanoleuca
11346 Homo sapiens
533531 Bos taurus
104027 Mus musculus
60324 Rattus norvegicus
100728174 Cavia porcellus
100344553 Oryctolagus cuniculus
479327 Canis lupus familiaris
770421 Gallus gallus
101110761 Ovis aries
100624154 Sus scrofa
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