anti-Sushi-Repeat Containing Protein, X-Linked (SRPX) Antikörper

Human Sushi-Repeat Containing Protein, X-Linked (SRPX) Interaktionspartner

1. SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.

2. The SRPX protein contains the P-DUDES structural domain in its C-terminal region. This domain has significant albeit remote sequence similarity to thioredoxin-like domains, and is predicted to possess an oxidoreductase function.

3. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.

4. An apoptosis-inducing protein localized in the endoplasmic reticulum which increases efficiency of apoptosis

5. expression of drs mRNA in well-differentiated, moderately differentiated, and poorly differentiated lung adenocarcinoma tissues (drs; down-regulated by v-scr)

6. down-regulation of drs mRNA is closely correlated with carcinomas which arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene

7. Down-regulation of drs mRNA is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer.

8. Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.

9. This is the first report demonstrating overexpression of ETX1 in glaucomatous trabecular meshwork.

Mouse (Murine) Sushi-Repeat Containing Protein, X-Linked (SRPX) Interaktionspartner

1. SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.

2. drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells.

3. Drs suppresses viral replication via mTOR-dependent pathway.

4. Isolation of a novel variant of the tumor suppressor gene (mDRS-2)

5. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs

6. drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes