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The protein encoded by ST14 is an epithelial-derived, integral membrane serine protease. Zusätzlich bieten wir Ihnen Suppression of Tumorigenicity 14 (Colon Carcinoma) Antikörper (111) und Suppression of Tumorigenicity 14 (Colon Carcinoma) Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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limited role for HAI-2 (zeige SPINT2 Proteine) in the inhibition of matriptase and prostasin (zeige PRSS8 Proteine) is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin (zeige PRSS8 Proteine) or matriptase
Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling.
Data, including data from studies using cadaver tissue, suggest that matriptase and matriptase mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase RNA are expressed in young individuals as compared to older individuals; matriptase cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102).
Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
The authors report that ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 (zeige ERBB2 Proteine) is not applicable.
These results identify EpCAM (zeige EPCAM Proteine) as a substrate of matriptase and link HAI-2 (zeige SPINT2 Proteine), matriptase, EpCAM (zeige EPCAM Proteine), and claudin-7 (zeige CLDN7 Proteine) in a functionally important pathway that causes disease when it is dysregulated.
Matriptase is present in macrophages from patients with mutated alpha-1 antitrypsin (zeige SERPINA1 Proteine) at high levels and contributes to their proteolytic activity on extracellular matrix. MMP-14 (zeige MMP14 Proteine) is a novel substrate for matriptase, which regulates the levels of MMP-14 (zeige MMP14 Proteine) on the cell surface. High levels of matriptase may contribute to increased ECM (zeige MMRN1 Proteine) degradation by Z-M, both directly and through MMP-14 (zeige MMP14 Proteine) activation.
Ultraviolet irradiation/reactive oxygen species induced matriptase proteolysis may have short term protective effects and contribute to the recovery from acute epidermal damage and/or pathology of skin with chronic sun damage.
The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1 (zeige SPINT1 Proteine). Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.
Given that matriptase-1 participates in terminal KC differentiation, its absence in psoriatic skin lesions indicates that this contributes to the barrier disturbances in this disease.
The proliferation impairment in matriptase-deficient breast cancer cells is caused by their inability to initiate activation of the c-Met signalling pathway in response to fibroblast-secreted pro-HGF (zeige HGF Proteine).
Matriptase is a critical promoter of late stages of squamous cell carcinoma progression and induces pro-tumorigenic chemokine (zeige CCL1 Proteine) and cytokine release, and inflammatory cell accumulation in established tumors.
Data show that proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated and potentiation of ras-mediated oncogenesis.
HAI-1 (zeige SPINT1 Proteine) regulates the activity of activated matriptase, whereas HAI-2 (zeige SPINT2 Proteine) has an essential role in regulating prostasin (zeige PRSS8 Proteine)-dependent matriptase zymogen activation.
Our results reveal unexpected complementary roles of matriptase-prostasin (zeige PRSS8 Proteine)- and PAR-2 (zeige F2RL1 Proteine)-dependent proteolytic signaling in the establishment of placental epithelial barrier function and overall embryonic survival.
These findings suggest that TGF-beta (zeige TGFB1 Proteine) induces epithin/PRSS14 shedding by mediating translocation of epithin/PRSS14 sheddase, TACE (zeige ADAM17 Proteine), to the membrane.
Matriptase deletion initiates a Sjogren's syndrome-like disease in mice.
Matriptase is required for the active form of hepatocyte growth factor (zeige HGF Proteine) induced Met, focal adhesion kinase and protein kinase B (zeige AKT1 Proteine) activation on neural stem/progenitor cell motility.
ST14 expression is downregulated in colitis.
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
membrane-type serine protease 1
, serine protease 14
, serine protease TADG-15
, suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
, suppressor of tumorigenicity 14 protein
, tumor associated differentially expressed gene 15 protein
, tumor-associated differentially-expressed gene 15 protein
, matriptase a
, suppression of tumorigenicity 14 (colon carcinoma) a
, suppressor of tumorigenicity 14 protein homolog
, suppressor of tumorigenicity protein 14
, protease, serine, 14 (epithin)
, membrane-type serine protease