Suppression of Tumorigenicity 14 (Colon Carcinoma) Proteine (ST14)

The protein encoded by ST14 is an epithelial-derived, integral membrane serine protease. Zusätzlich bieten wir Ihnen Suppression of Tumorigenicity 14 (Colon Carcinoma) Antikörper (108) und Suppression of Tumorigenicity 14 (Colon Carcinoma) Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ST14 6768 Q9Y5Y6
ST14 19143 P56677
Ratte ST14 ST14 114093  
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 60 bis 65 Tage
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
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ST14 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14) Interaktionspartnern

Human Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14) Interaktionspartner

  1. Our findings suggest that the high stromal matriptase expression was strongly associated with tumor progression, recurrence and poor outcomes in patients with extrahepatic bile duct cancer.

  2. used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of cytoskeletal and ECM peptides to the ST14 protease; Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme.

  3. the data strongly advocate this ST14 variant as the underlying genetic cause of autosomal recessive ichthyosis with hypotrichosis syndrome in this first reported affected family from Pakistan. Moreover, the present study adds to the spectrum of mutations in the ST14 gene, implicating them in the pathogenesis of autosomal recessive ichthyosis with hypotrichosis syndrome.

  4. limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase

  5. Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling.

  6. Data, including data from studies using cadaver tissue, suggest that matriptase and matriptase mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase RNA are expressed in young individuals as compared to older individuals; matriptase cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102).

  7. Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.

  8. The authors report that ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 is not applicable.

  9. These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.

  10. Matriptase is present in macrophages from patients with mutated alpha-1 antitrypsin at high levels and contributes to their proteolytic activity on extracellular matrix. MMP-14 is a novel substrate for matriptase, which regulates the levels of MMP-14 on the cell surface. High levels of matriptase may contribute to increased ECM degradation by Z-M, both directly and through MMP-14 activation.

  11. Ultraviolet irradiation/reactive oxygen species induced matriptase proteolysis may have short term protective effects and contribute to the recovery from acute epidermal damage and/or pathology of skin with chronic sun damage.

  12. The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.

  13. Given that matriptase-1 participates in terminal KC differentiation, its absence in psoriatic skin lesions indicates that this contributes to the barrier disturbances in this disease.

  14. Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis.

  15. Maritriptase is required for pro-HGF/c-Met signaling and cell proliferation in breast cancer cells.

  16. Matriptase inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

  17. prostate cancer cell invasion is stimulated by a rapid but sustained increase in Src activity, mediated non-genomically by cytoplasmic AR, leading to rapid activation and shedding of the laminin protease Matriptase

  18. Report potent/specific inhibition of matriptase by the cyclic microprotein MCoTI-II.

  19. Matriptase expression correlates with tumour progression and invasive capability in oral squamous cell carcinoma

  20. Matriptase can act as a cellular sensor of the chemical environment of the cell that allows the cell to respond to and protect itself from changes in the chemical milieu.

Mouse (Murine) Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14) Interaktionspartner

  1. These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.

  2. The proliferation impairment in matriptase-deficient breast cancer cells is caused by their inability to initiate activation of the c-Met signalling pathway in response to fibroblast-secreted pro-HGF.

  3. Matriptase is a critical promoter of late stages of squamous cell carcinoma progression and induces pro-tumorigenic chemokine and cytokine release, and inflammatory cell accumulation in established tumors.

  4. Data show that proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated and potentiation of ras-mediated oncogenesis.

  5. HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation.

  6. Our results reveal unexpected complementary roles of matriptase-prostasin- and PAR-2-dependent proteolytic signaling in the establishment of placental epithelial barrier function and overall embryonic survival.

  7. These findings suggest that TGF-beta induces epithin/PRSS14 shedding by mediating translocation of epithin/PRSS14 sheddase, TACE, to the membrane.

  8. Matriptase deletion initiates a Sjogren's syndrome-like disease in mice.

  9. Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility.

  10. ST14 expression is downregulated in colitis.

  11. St14 is a critical tumor-suppressor gene in the mouse gastrointestinal tract and adds matriptase to the expanding list of pericellular proteases with tumor-suppressive functions

  12. Overexpression of matriptase in 4T1 mouse breast carcinoma cells resulted in visible changes in morphology, actin staining and cell to cell contacts

  13. matriptase as an initiator of c-Met-Akt-mTor-dependent signaling axis in tumors and mTor activation as an essential component of matriptase/c-Met-induced carcinogenesis

  14. Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.

  15. Soluble form of the protein secreted from cancer cells contains active angiogenic potential

  16. These results suggest that epithin is a key mediator of TGF-beta-induced epithelial-mesenchymal transition in tumor progression.

  17. Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation

  18. Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. (Matriptase/MTSP1)

  19. matriptase is downregulated through suppression of activation of receptor-bound pro-urokinase, and leads to inhibition of tumor invasion

  20. identification of an epithin isoform, epithin(Delta), containing a 66 amino acid deletion from the full-length epithin, which is missing the 4th LDLRA domain and the protease activation sequence

Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14) Protein Überblick

Protein Überblick

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Genbezeichner und Symbole assoziert mit ST14

  • suppression of tumorigenicity 14 (ST14)
  • suppression of tumorigenicity 14 L homeolog (st14.L)
  • suppression of tumorigenicity 14 (colon carcinoma) (St14)
  • suppression of tumorigenicity 14 (St14)
  • Epithin Protein
  • hai Protein
  • matriptase Protein
  • mCAP3 Protein
  • mt-sp1 Protein
  • mtsp1 Protein
  • Prss14 Protein
  • snc19 Protein
  • st14 Protein
  • st14a Protein
  • tadg15 Protein
  • tmprss1 Protein
  • Tmprss14 Protein
  • XMT-SP1 Protein

Bezeichner auf Proteinebene für ST14

membrane-type serine protease 1 , prostamin , serine protease 14 , serine protease TADG-15 , suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) , suppressor of tumorigenicity 14 protein , tumor associated differentially expressed gene 15 protein , tumor-associated differentially-expressed gene 15 protein , matriptase a , suppression of tumorigenicity 14 (colon carcinoma) a , suppressor of tumorigenicity 14 protein homolog , suppressor of tumorigenicity protein 14 , matriptase/MT-SP1 , protease, serine, 14 (epithin) , matriptase , membrane-type serine protease

GENE ID SPEZIES
100101609 Oryctolagus cuniculus
6768 Homo sapiens
394363 Xenopus laevis
767617 Bos taurus
19143 Mus musculus
114093 Rattus norvegicus
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