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Our findings suggest that the high stromal matriptase expression was strongly associated with tumor progression, recurrence and poor outcomes in patients with extrahepatic bile duct cancer.
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used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of cytoskeletal and ECM peptides to the ST14 protease; Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme.
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the data strongly advocate this ST14 variant as the underlying genetic cause of autosomal recessive ichthyosis with hypotrichosis syndrome in this first reported affected family from Pakistan. Moreover, the present study adds to the spectrum of mutations in the ST14 gene, implicating them in the pathogenesis of autosomal recessive ichthyosis with hypotrichosis syndrome.
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limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase
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Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling.
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Data, including data from studies using cadaver tissue, suggest that matriptase and matriptase mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase RNA are expressed in young individuals as compared to older individuals; matriptase cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102).
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Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
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The authors report that ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 is not applicable.
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These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.
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Matriptase is present in macrophages from patients with mutated alpha-1 antitrypsin at high levels and contributes to their proteolytic activity on extracellular matrix. MMP-14 is a novel substrate for matriptase, which regulates the levels of MMP-14 on the cell surface. High levels of matriptase may contribute to increased ECM degradation by Z-M, both directly and through MMP-14 activation.
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Ultraviolet irradiation/reactive oxygen species induced matriptase proteolysis may have short term protective effects and contribute to the recovery from acute epidermal damage and/or pathology of skin with chronic sun damage.
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The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.
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Given that matriptase-1 participates in terminal KC differentiation, its absence in psoriatic skin lesions indicates that this contributes to the barrier disturbances in this disease.
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Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis.
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Maritriptase is required for pro-HGF/c-Met signaling and cell proliferation in breast cancer cells.
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Matriptase inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.
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prostate cancer cell invasion is stimulated by a rapid but sustained increase in Src activity, mediated non-genomically by cytoplasmic AR, leading to rapid activation and shedding of the laminin protease Matriptase
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Report potent/specific inhibition of matriptase by the cyclic microprotein MCoTI-II.
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Matriptase expression correlates with tumour progression and invasive capability in oral squamous cell carcinoma
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Matriptase can act as a cellular sensor of the chemical environment of the cell that allows the cell to respond to and protect itself from changes in the chemical milieu.
