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SOAT2 is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. Zusätzlich bieten wir Ihnen SOAT2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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TG-interacting factor 1 (Tgif1 (zeige TGIF1 Antikörper)) is an important repressor of SOAT2 gene expression.
CDX2 (zeige CDX2 Antikörper), a known positive regulator of hepatocyte differentiation, was regulated by miR (zeige MLXIP Antikörper)-181d and directly activated SOAT2 gene expression.
We found a new single-nucleotide polymorphism (SNP; a point mutation in intron 1, IVS1 -8 G-->C) in the ACAT-2 gene. Our data suggest that the ACAT-2 gene may not affect lipid levels in humans.
Fully differentiated macrophages express ACAT2 (zeige ACAT2 Antikörper) in addition to ACAT1 (zeige ACAT1 Antikörper) under various pathologic conditions.
ACAT-1 transcripts predominate in human liver and ACAT-2 transcripts predominate in human duodenum and support the notion that ACAT-2 has an important regulatory role in liver and intestine.
increasing DGAT1, ACAT1, or ACAT2 expression stimulates the assembly and secretion of VLDL from liver cells
ACAT2 provided the major cholesterol-esterifying activity in 3 of 4 human liver samples.
transcription factors hepatic nuclear factor 1 (HNF1)alpha (zeige HNF1A Antikörper) and beta play an important part in the regulation of the ACAT2 (zeige ACAT2 Antikörper) promoter
The structural features of various sterols as substrates and/or activators of ACAT1 and ACAT2 in vitro are reported.
Serum-induced depletion of cellular cholesterol available for esterification by ACAT (zeige SOAT1 Antikörper) was a strong, independent predictor of major adverse cardiovascular events and death.
These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.
Hepatic knockdown of SOAT2 in apoB100 (zeige APOB Antikörper)-only, LDLr (zeige LDLR Antikörper)(-/-) mice resulted in remodeling of aortic atherosclerotic lesions into a stable phenotype, suggesting SOAT2 is a viable target for the treatment of atherosclerosis.
SOAT2 causes hepatic cholesterol to be swiftly mobilized and packaged onto nascent lipoproteins that feed cholesterol into the TICE pathway for fecal excretion.
effect the loss of SOAT2 function has on tissue esterified cholesterol sequestration in lysosomal acid lipase (zeige LIPA Antikörper)-deficient mice in a model of cholesteryl ester storage disease
Aortic atherosclerosis development was significantly lower in SOAT2 knock-out mice.
ACAT2 increases cholesterol absorption efficiency by providing cholesterol esters for chylomicron transport, but 1 copy of the Acat2 gene, providing approximately 50% of ACAT2 mRNA and enzyme activity, was as effective as 2 copies in promoting cholesterol absorption.
ACAT2-derived cholesterol esters have a crucial role in the development of atherosclerosis in mice
ACAT2 displays a greater capacity than ACAT1 (zeige SOAT1 Antikörper) to differentiate cholesterol from sitosterol
ACAT2-derived cholesteryl ester is the predominant atherogenic lipid in blood.
ACAT2 deficiency limits cholesterol absorption. Extent it impacts hepatic cholesterol homeostasis depends on cholesterol intake. Loss of ACAT2 activity may result in unesterified cholesterol being absorbed via ABCA1 (zeige ABCA1 Antikörper)-mediated basolateral efflux pathway.
These results indicated that zebrafish Soat2 is catalytically active in synthesizing cholesteryl esters and contributes to the yolk cholesterol trafficking during zebrafish embryogenesis.
This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
, acyl Co-A: cholesterol acyltransferase 2
, acyl coenzyme A:cholesterol acyltransferase 2
, acyl-CoA:cholesterol acyltransferase 2
, acyl-coenzyme A:cholesterol acyltransferase 2
, cholesterol acyltransferase 2
, acyl-CoA:cholesterol acyltransferase
, sterol O-acyltransferase 2
, acyl coenzyme A cholesterol acyltransferase 2