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STMN2 encodes a member of the stathmin family of phosphoproteins. Zusätzlich bieten wir Ihnen Stathmin-Like 2 Proteine (10) und Stathmin-Like 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal STMN2 Primary Antibody für ICC, IF - ABIN4356489
Shin, Cho, Beirowski, Milbrandt, Cavalli, DiAntonio: Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. in Neuron 2012
Show all 8 Pubmed References
Mammalian Monoclonal STMN2 Primary Antibody für ISt, IHC - ABIN1304947
Sobczak, Debowska, Blazejczyk, Kreutz, Kuznicki, Wojda: Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. in Biochimica et biophysica acta 2011
Show all 5 Pubmed References
Human Polyclonal STMN2 Primary Antibody für ELISA, WB - ABIN250188
Bahn, Mimmack, Ryan, Caldwell, Jauniaux, Starkey, Svendsen, Emson: Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. in Lancet 2002
Zeb (zeige KIAA1279 Antikörper)rafish studies further demonstrated an epistatic interaction between KBP and SCG10 in vivo.
Results provide a starting point for future studies that will investigate the in vivo function of SCG10 orthologues in zebrafish neural development.
RARB (zeige RARB Antikörper) and STMN2 polymorphisms were not associated with sporadic CJD (zeige PRNP Antikörper) in the Korean population.
PAK4 (zeige PAK4 Antikörper)-SCG10 signaling occurs in gastric cancer cell invasion.
STMN and SCG10 are similarly targeted by JNK (zeige MAPK8 Antikörper) but there are clear differences in JNK (zeige MAPK8 Antikörper) recognition and phosphorylation of the closely related family member, SCLIP (zeige STMN3 Antikörper).
CaMy1 via SCG10 couples Ca(2 (zeige CA2 Antikörper)+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain.
SCG10 is upregulated in the IKAP/Elp1 (zeige IKBKAP Antikörper)-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics
Overexpression of SCG10 is associated with Liver Fibrosis.
RGS6 (zeige RGS6 Antikörper) interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL (zeige GGT5 Antikörper)) domain of RGS6 (zeige RGS6 Antikörper)
STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin (zeige CTNNB1 Antikörper)/TCF (zeige HNF4A Antikörper)-activated hepatoma cells
activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin (zeige TUBB Antikörper) for net plus end elongation
Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1 (zeige MAPK8 Antikörper)) effector of regeneration.
autophagy induction stabilized microtubules by degrading SCG10, a microtubule disassembly protein in neurons. In mice with spinal cord injury, local administration of a specific autophagy-inducing peptide, Tat (zeige TAT Antikörper)-beclin1 (zeige BECN1 Antikörper), to lesion sites markedly attenuated axonal retraction of spinal dorsal column axons and cortical spinal tract and promoted regeneration of descending axons following long-term observation
SCG10 promotes non-amyloidogenic processing of amyloid precursor protein (zeige APP Antikörper) by facilitating its trafficking to the cell surface.
This study demonstrated that axonal injury induces a dynamic regulation of SCG10 protein levels with selective accumulation in proximal axon segments.
JNK (zeige MAPK8 Antikörper) phosphorylation targets SCG10 for degradation.
SCG10 is not directly implicated in Hirschsprung diseased evelopment
the Rarb (zeige RARB Antikörper) region of Mmu14 and Stmn2, but not Cr1 (zeige TDGF1 Antikörper) or Clu (zeige CLU Antikörper) or Picalm (zeige PICALM Antikörper) have roles in prion (zeige PRNP Antikörper) disease
These findings indicate that the phosphorylation of SCG10 by JNK1 (zeige MAPK8 Antikörper) is a fundamental mechanism that governs the transition from the multipolar stage and the rate of neuronal cell movement during cortical development.
KBP binds exclusively to microtubule associated or related proteins, specifically SCG10.
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.
, stathmin-like 2c
, superiorcervical ganglia, neural specific 10
, neuron-specific growth-associated protein
, neuronal growth-associated protein (silencer element)
, superior cervical ganglia, neural specific 10
, superior cervical ganglion-10 protein
, stathmin 2