anti-Stathmin-Like 2 (STMN2) Antikörper

Zebrafish Stathmin-Like 2 (STMN2) Interaktionspartner

1. Zebrafish studies further demonstrated an epistatic interaction between KBP and SCG10 in vivo.

2. Results provide a starting point for future studies that will investigate the in vivo function of SCG10 orthologues in zebrafish neural development.

Human Stathmin-Like 2 (STMN2) Interaktionspartner

1. expression of STMN2, which encodes a microtubule regulator, declined after TDP-43 knockdown and TDP-43 mislocalization as well as in patient-specific motor neurons and postmortem patient spinal cord. STMN2 loss upon reduced TDP-43 function was due to altered splicing, which is functionally important, as we show STMN2 is necessary for normal axonal outgrowth and regeneration.

2. premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability.

3. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population.

4. PAK4-SCG10 signaling occurs in gastric cancer cell invasion.

5. STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP.

6. CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain.

7. SCG10 is upregulated in the IKAP/Elp1-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics

8. Overexpression of SCG10 is associated with Liver Fibrosis.

9. RGS6 interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of RGS6

10. STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells

11. activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin for net plus end elongation

12. Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1) effector of regeneration.

13. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.

14. SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi.

15. STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance.

16. SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.

Mouse (Murine) Stathmin-Like 2 (STMN2) Interaktionspartner

1. autophagy induction stabilized microtubules by degrading SCG10, a microtubule disassembly protein in neurons. In mice with spinal cord injury, local administration of a specific autophagy-inducing peptide, Tat-beclin1, to lesion sites markedly attenuated axonal retraction of spinal dorsal column axons and cortical spinal tract and promoted regeneration of descending axons following long-term observation

2. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface.

3. This study demonstrated that axonal injury induces a dynamic regulation of SCG10 protein levels with selective accumulation in proximal axon segments.

4. JNK phosphorylation targets SCG10 for degradation.

5. SCG10 is not directly implicated in Hirschsprung diseased evelopment

6. the Rarb region of Mmu14 and Stmn2, but not Cr1 or Clu or Picalm have roles in prion disease

7. These findings indicate that the phosphorylation of SCG10 by JNK1 is a fundamental mechanism that governs the transition from the multipolar stage and the rate of neuronal cell movement during cortical development.

8. KBP binds exclusively to microtubule associated or related proteins, specifically SCG10.