StAR-Related Lipid Transfer (START) Domain Containing 7 Proteine (STARD7)

Human StAR-Related Lipid Transfer (START) Domain Containing 7 (STARD7) Interaktionspartner

1. PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol

2. The results indicate that StarD7 contributes to the modulation of cellular redox homeostasis.

3. MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC.

4. StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model.

5. StarD7 behaves as a fusogenic protein in model and cell membrane bilayers.

6. The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development.

7. These results suggest that StarD7 facilitates the delivery of phosphatidylcholine to mitochondria in non-vesicular system.

8. Beta-catenin and TCF4 activate the human StarD7 gene interacting with its promoter region through Wnt/beta-catenin signalling.

9. the apparent occurrence of an unusual TG 3' splice site in intron 1 is discussed

Mouse (Murine) StAR-Related Lipid Transfer (START) Domain Containing 7 (STARD7) Interaktionspartner

1. These findings indicate that StarD7 plays important roles in maintaining the proper composition of mitochondrial phospholipids as well as mitochondrial function and morphogenesis.

2. these data suggest that Stard7 is an important component of a novel protective pathway in tissues exposed to the extracellular environment.