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Although the function of STARD7 is not known, its existence is supported by mRNA and EST data.
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The results indicate that StarD7 contributes to the modulation of cellular redox homeostasis.
MFSD2B, CCL20 (zeige CCL20 Proteine) and STAT1 (zeige STAT1 Proteine), or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC (zeige ADC Proteine); HTR2B (zeige HTR2B Proteine), DPP4 (zeige DPP4 Proteine), and TGFBRAP1 (zeige TGFBRAP1 Proteine) genes may be risk factors in prognosis of SQC (zeige QPCT Proteine).
StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model.
StarD7 behaves as a fusogenic protein in model and cell membrane bilayers.
The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development.
These results suggest that StarD7 facilitates the delivery of phosphatidylcholine (zeige SGMS2 Proteine) to mitochondria in non-vesicular system.
Beta-catenin (zeige CTNNB1 Proteine) and TCF4 (zeige TCF4 Proteine) activate the human StarD7 gene interacting with its promoter region through Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling.
These findings indicate that StarD7 plays important roles in maintaining the proper composition of mitochondrial phospholipids as well as mitochondrial function and morphogenesis.
these data suggest that Stard7 is an important component of a novel protective pathway in tissues exposed to the extracellular environment.
Although the function of this gene is not known, its existence is supported by mRNA and EST data. The predicted gene product contains a region similar to the STAR-related lipid transfer (START) domain, which is often present in proteins involved in the cell signaling mediated by lipid binding. Alternatively spliced transcript variants have been described, although some transcripts occur only in cancer cell lines.
START domain containing 7
, stAR-related lipid transfer protein 7, mitochondrial
, START domain-containing protein 7
, gestational trophoblastic tumor protein 1