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SKAP1 encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. Zusätzlich bieten wir Ihnen SKAP1 Antikörper (78) und viele weitere Produktgruppen zu diesem Protein an.
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SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation
this study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis
In this study, the authors identified that the ADAP (zeige APP Proteine)-SKAP55 signaling module reduced CD8 (zeige CD8A Proteine)(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 (zeige PDCD1 Proteine) expression in a Fyn (zeige FYN Proteine)-, Ca(2 (zeige CA2 Proteine)+)-, and NFATc1 (zeige NFATC1 Proteine)-dependent manner.
Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP (zeige APP Proteine).
HPK1 (zeige MAP4K1 Proteine) associates with SKAP1 to negatively regulate Rap1 (zeige TERF2IP Proteine)-mediated B-lymphocyte (zeige AKAP17A Proteine) adhesion.
SKAP1 is dispensable for both CXCL12 (zeige CXCL12 Proteine) and CCL21 (zeige CCL21 Proteine) induced T-cell migration.
findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (zeige RASSF5 Proteine) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal.
K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (zeige ITGAL Proteine).
SKAP55 dimers stabilize SLP-76 (zeige LCP2 Proteine) microclusters, couple SLP-76 (zeige LCP2 Proteine) to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM (zeige APBB1IP Proteine), talin, and beta1 integrins.
single-nucleotide polymorphisms in ARRDC3, FLT1 (zeige FLT1 Proteine), and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients.
N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL (zeige RASSF5 Proteine) membrane and Rap1 (zeige RABGEF1 Proteine) binding and effectively substituted for PI3K (zeige PIK3CA Proteine) and TCR ligation in the activation of LFA-1 (zeige ITGAL Proteine) in T cells.
Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer.
SKAP55 coupled with CD45 (zeige PTPRC Proteine) positively regulates T-cell receptor-mediated gene transcription.
observation that adapter protein (zeige TOLLIP Proteine) SKAP55 formed homodimers through its SH3 domain (zeige ITSN1 Proteine) and SK region
SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells
stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
ortholog of human src family associated phosphoprotein 1 SCAP1
, src family-associated phosphoprotein 1
, src kinase-associated phosphoprotein 1
, src family associated phosphoprotein 1
, src kinase-associated phosphoprotein of 55 kDa
, SKAP55 adapter protein
, SKAP55 adaptor protein