Src Kinase Associated phosphoprotein 1 Proteine (SKAP1)

SKAP1 encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. Zusätzlich bieten wir Ihnen SKAP1 Antikörper (78) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SKAP1 78473 Q3UUV5
SKAP1 8631 Q86WV1
SKAP1 286975 Q4V7G1
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top SKAP1 Proteine auf antikoerper-online.de

Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,937.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,964.50
Details
Hefe Takifugu rubripes His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,992.00
Details
Escherichia coli (E. coli) Human His-SUMO Tag   100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Escherichia coli (E. coli) Maus T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$691.00
Details
Escherichia coli (E. coli) Ratte T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$707.00
Details

SKAP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , , ,
, , ,
Rat (Rattus) ,
,

Weitere Proteine zu Src Kinase Associated phosphoprotein 1 (SKAP1) Interaktionspartnern

Mouse (Murine) Src Kinase Associated phosphoprotein 1 (SKAP1) Interaktionspartner

  1. SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation

  2. this study shows that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis

  3. In this study, the authors identified that the ADAP (zeige APP Proteine)-SKAP55 signaling module reduced CD8 (zeige CD8A Proteine)(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 (zeige PDCD1 Proteine) expression in a Fyn (zeige FYN Proteine)-, Ca(2 (zeige CA2 Proteine)+)-, and NFATc1 (zeige NFATC1 Proteine)-dependent manner.

  4. Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP (zeige APP Proteine).

  5. HPK1 (zeige MAP4K1 Proteine) associates with SKAP1 to negatively regulate Rap1 (zeige TERF2IP Proteine)-mediated B-lymphocyte (zeige AKAP17A Proteine) adhesion.

  6. SKAP1 is dispensable for both CXCL12 (zeige CXCL12 Proteine) and CCL21 (zeige CCL21 Proteine) induced T-cell migration.

  7. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (zeige RASSF5 Proteine) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.

  8. Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal.

Human Src Kinase Associated phosphoprotein 1 (SKAP1) Interaktionspartner

  1. K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (zeige ITGAL Proteine).

  2. SKAP55 dimers stabilize SLP-76 (zeige LCP2 Proteine) microclusters, couple SLP-76 (zeige LCP2 Proteine) to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM (zeige APBB1IP Proteine), talin, and beta1 integrins.

  3. single-nucleotide polymorphisms in ARRDC3, FLT1 (zeige FLT1 Proteine), and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients.

  4. N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL (zeige RASSF5 Proteine) membrane and Rap1 (zeige RABGEF1 Proteine) binding and effectively substituted for PI3K (zeige PIK3CA Proteine) and TCR ligation in the activation of LFA-1 (zeige ITGAL Proteine) in T cells.

  5. Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer.

  6. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (zeige RASSF5 Proteine) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.

  7. SKAP55 coupled with CD45 (zeige PTPRC Proteine) positively regulates T-cell receptor-mediated gene transcription.

  8. observation that adapter protein (zeige TOLLIP Proteine) SKAP55 formed homodimers through its SH3 domain (zeige ITSN1 Proteine) and SK region

  9. SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells

  10. stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation

SKAP1 Protein Überblick

Protein Überblick

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Genbezeichner und Symbole assoziert mit SKAP1

  • src family associated phosphoprotein 1 (Skap1)
  • src kinase associated phosphoprotein 1 (SKAP1)
  • src kinase associated phosphoprotein 1 (Skap1)
  • 1700091G21Rik Protein
  • SCAP1 Protein
  • Skap-55 Protein
  • Skap55 Protein

Bezeichner auf Proteinebene für SKAP1

ortholog of human src family associated phosphoprotein 1 SCAP1 , src family-associated phosphoprotein 1 , src kinase-associated phosphoprotein 1 , SKAP-55 , pp55 , src family associated phosphoprotein 1 , src kinase-associated phosphoprotein of 55 kDa , SKAP55 adapter protein , SKAP55 adaptor protein

GENE ID SPEZIES
78473 Mus musculus
8631 Homo sapiens
286975 Rattus norvegicus
Ausgewählte Anbieter für SKAP1 Proteine (SKAP1)
Haben Sie etwas anderes gesucht?