Splicing Factor 3b, Subunit 4, 49kDa Proteine (SF3B4)

SF3B4 encodes one of four subunits of the splicing factor 3B. Zusätzlich bieten wir Ihnen Splicing Factor 3b, Subunit 4, 49kDa Antikörper (94) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SF3B4 107701 Q8QZY9
Ratte SF3B4 SF3B4 295270 Q6AYL5
SF3B4 10262 Q15427
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,905.83
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Hefe Caenorhabditis elegans His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,070.83
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SF3B4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Interaktionspartnern

Xenopus laevis Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Interaktionspartner

  1. Sf3b4-depleted embryos show reduced expression of the neural crest genes sox10 (zeige SOX10 Proteine), snail2 and twist at the neural plate border, associated with a broadening of the neural plate. This phenotype can be rescued by injection of wild-type human SF3B4 mRNA but not by mRNAs carrying mutations that cause Nager syndrome.

Human Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Interaktionspartner

  1. We identified two heterozygous frameshift mutations in the SF3B4 gene in three of the four fetuses investigated. The observed mutation was apparently de novo in one fetus for whom parental DNA was available. Thus, Acrofacial dysostosis syndrome of Rodriguez is an autosomal dominant condition and the recurrences identified in the initial report were likely due to gonadal mosaicism.

  2. A novel synonymous variant within exon 3 of the SF3B4 gene was identified in three members of a family affected by Nager syndrome.

  3. Chemical shift mapping showed that the SF3b145 (zeige SF3B2 Proteine) fragment spanning residues 598-631 interacts with SF3b49 RRM1 (zeige RRM1 Proteine), which adopts a canonical RRM fold with a topology of beta1-alpha1-beta2-beta3-alpha2-beta4.

  4. SF3B4 mutations identified in Rodriguez Acrofacial Dysostosis patients disrupted mRNA splicing and reduced expression of DLX5, DLX6, SOX9, and SOX6 in cultured chondrocytes.

  5. splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 (zeige STAT3 Proteine) signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 (zeige STAT3 Proteine) on a tyrosine residue at position 705.

  6. Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC (zeige FAM126A Proteine)

  7. High SF3B4 expression is associated with hepatocellular carcinoma.

  8. SF3B4 haploinsufficiency confirmed as the major cause of Nager syndrome.

  9. SF3B4 mutation is associated with Nager syndrome.

  10. These results suggest that most cases of Nager syndrome are caused by haploinsufficiency of SF3B4.

Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Protein Überblick

Protein Überblick

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.

Genbezeichner und Symbole assoziert mit SF3B4

  • Splicing factor 3B subunit 4 (sap-49)
  • splicing factor 3b, subunit 4 (sf3b4)
  • splicing factor 3b, subunit 4 (Sf3b4)
  • splicing factor 3b subunit 4 S homeolog (sf3b4.S)
  • splicing factor 3b subunit 4 (SF3B4)
  • 49kDa Protein
  • AFD1 Protein
  • chunp6902 Protein
  • fb36a04 Protein
  • Hsh49 Protein
  • SAP49 Protein
  • SF3b49 Protein
  • SF3b50 Protein
  • spx Protein
  • wu:fb36a04 Protein

Bezeichner auf Proteinebene für SF3B4

splicing factor 3B subunit 4 , splicing factor 3b, subunit 4, 49kD , spliceosome associated protein 49 , SAP 49 , SF3b50 , pre-mRNA-splicing factor SF3b 49 kDa subunit , spliceosomal protein , spliceosome-associated protein (U2 snRNP) , spliceosome-associated protein 49

GENE ID SPEZIES
4363023 Caenorhabditis elegans
192318 Danio rerio
107701 Mus musculus
295270 Rattus norvegicus
379792 Xenopus laevis
10262 Homo sapiens
483177 Canis lupus familiaris
506123 Bos taurus
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