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Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Zusätzlich bieten wir Ihnen SPSB1 Antikörper (12) und viele weitere Produktgruppen zu diesem Protein an.
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EGF (zeige EGF Proteine) signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B (zeige TCEB2 Proteine)/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1 (zeige HNRNPA1 Proteine).
SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.
SSB1 (zeige SSBP1 Proteine)/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.
Collectively, Ssb1 and Ssb2 (zeige SPSB2 Proteine) control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.
These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2 (zeige SPSB2 Proteine), controls the extent of iNOS (zeige NOS2 Proteine) induction and nitric oxide production.
SPSB1 and SPSB4 (zeige SPSB4 Proteine) bind strongly to both Par-4 (zeige F2RL3 Proteine) and VASA (zeige DDX4 Proteine) peptides.
Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
SPRY domain-containing SOCS box protein 1
, SPRY domain-containing SOCS box protein SSB-1
, novel SPRY domain containing protein