SplA/ryanodine Receptor Domain and SOCS Box Containing 1 Proteine (SPSB1)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Zusätzlich bieten wir Ihnen SPSB1 Antikörper (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SPSB1 80176 Q96BD6
SPSB1 74646 Q9D5L7
SPSB1 504407 Q5E9X6
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Top SPSB1 Proteine auf antikoerper-online.de

Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$492.31
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,713.33
Details

SPSB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Cow (Bovine)

Weitere Proteine zu SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) Interaktionspartnern

Human SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) Interaktionspartner

  1. EGF (zeige EGF Proteine) signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B (zeige TCEB2 Proteine)/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1 (zeige HNRNPA1 Proteine).

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. SSB1 (zeige SSBP1 Proteine)/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.

Mouse (Murine) SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) Interaktionspartner

  1. Collectively, Ssb1 and Ssb2 (zeige SPSB2 Proteine) control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.

  4. These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2 (zeige SPSB2 Proteine), controls the extent of iNOS (zeige NOS2 Proteine) induction and nitric oxide production.

  5. SPSB1 and SPSB4 (zeige SPSB4 Proteine) bind strongly to both Par-4 (zeige F2RL3 Proteine) and VASA (zeige DDX4 Proteine) peptides.

  6. Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.

SPSB1 Protein Überblick

Protein Überblick

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Genbezeichner und Symbole assoziert mit SPSB1

  • splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1)
  • splA/ryanodine receptor domain and SOCS box containing 1 (Spsb1)
  • 1110014L01Rik Protein
  • 4930422J18Rik Protein
  • AI596360 Protein
  • AI854583 Protein
  • SSB-1 Protein
  • SSB1 Protein

Bezeichner auf Proteinebene für SPSB1

SPRY domain-containing SOCS box protein 1 , SPRY domain-containing SOCS box protein SSB-1 , novel SPRY domain containing protein , SSB-1

GENE ID SPEZIES
80176 Homo sapiens
74646 Mus musculus
504407 Bos taurus
Ausgewählte Anbieter für SPSB1 Proteine (SPSB1)
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