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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Zusätzlich bieten wir Ihnen SP7 Antikörper (37) und SP7 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Results showed that blocking miR (zeige MLXIP ELISA Kits)-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin (zeige BGLAP ELISA Kits) at day 21, suggesting MSC (zeige MSC ELISA Kits) osteogenesis
Results provide evidence that CBP (zeige CREBBP ELISA Kits)-mediated acetylation and HDAC4 (zeige HDAC4 ELISA Kits)-mediated deacetylation have critical roles in the modification of Osx (zeige MID1 ELISA Kits), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (zeige RUNX2 ELISA Kits) are transcriptional regulators of sclerostin (zeige SOST ELISA Kits) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14, which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (zeige TYMP ELISA Kits) ) curbed the expression of three proteins-IRF8 (zeige IRF8 ELISA Kits), RUNX2 (zeige RUNX2 ELISA Kits), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (zeige CADM1 ELISA Kits) and Osterix respectively. The other markers showed no statistical significance(CD151 (zeige CD151 ELISA Kits),ALP (zeige ALP ELISA Kits)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (zeige CADM1 ELISA Kits) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (zeige BMP4 ELISA Kits)-induced Cx43 (zeige GJA1 ELISA Kits) activity.
The expression of specific targets Smad1 (zeige GARS ELISA Kits) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (zeige MUC7 ELISA Kits)+). As miR (zeige MLXIP ELISA Kits)-30b, miR (zeige MLXIP ELISA Kits)-133a, and miR (zeige MLXIP ELISA Kits)-143 are negatively regulated by Pi and restored by Mg(2 (zeige MUC7 ELISA Kits)+) with a congruent modulation of their known targets Runx2 (zeige RUNX2 ELISA Kits), Smad1 (zeige GARS ELISA Kits), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (zeige WNT2 ELISA Kits)/beta-Catenin (zeige CTNNB1 ELISA Kits) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
these findings strongly suggest that TGF-beta (zeige TGFB1 ELISA Kits) signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (zeige TGFBR2 ELISA Kits) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (zeige TGFBR2 ELISA Kits)(fl/fl (zeige FLT3LG ELISA Kits)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (zeige MMP13 ELISA Kits) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH ELISA Kits), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (zeige WNT3A ELISA Kits) induces Osx expression via p38 MAPK (zeige MAPK14 ELISA Kits) signaling in dental follicle cells. Wnt3a (zeige WNT3A ELISA Kits)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (zeige MAPK14 ELISA Kits) (MAPK (zeige MAPK1 ELISA Kits)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (zeige KLK6 ELISA Kits) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (zeige KLK6 ELISA Kits) promoter activated by Osx, a series of deletion mutants of Bsp (zeige KLK6 ELISA Kits) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (zeige RELB ELISA Kits) site was required for Bsp (zeige KLK6 ELISA Kits) promoter activation by Osx.
OSX served a key role in the development and progression of ALD (zeige ABCD1 ELISA Kits)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2-induced osteogenic differentiation of BMSCs is regulated by miR (zeige MLXIP ELISA Kits)-27a.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7