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SNX2 encodes a member of the sorting nexin family. Zusätzlich bieten wir Ihnen Sorting Nexin 2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Dog (Canine) Monoclonal SNX2 Primary Antibody für IF, WB - ABIN968465
Haft, de la Luz Sierra, Barr, Haft, Taylor: Identification of a family of sorting nexin molecules and characterization of their association with receptors. in Molecular and cellular biology 1998
Show all 2 Pubmed References
SNX2 is highly expressed in 73.3% Graves disease patients and in 93.8% thyroid nodule patients.
Silencing of SNX2 markedly alters sensitivity to anticancer drugs targeted to c-Met.
SNX1 and SNX2 interact with the Rac1 and RhoG guanine nucleotide exchange factor Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
Examined the effect of a PX domain-mutated SNX2 that is defective in vesicle localization on EGFR (zeige EGFR Antikörper) trafficking.
The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 suggesting that PX domains may also participate in protein-protein interaction
Data suggest that sorting nexin-2 is not essential for the regulation of endosome-to-trans Golgi network retrieval of the cation-independent mannose 6-phosphate receptor (zeige IGF2R Antikörper).
These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1 (zeige SNX1 Antikörper)/2 and Vps26 (zeige VPS26A Antikörper)-Vps29 (zeige VPS29 Antikörper)-Vps35 (zeige vps35 Antikörper) subcomplexes on endosomal membranes and that SNX1 (zeige SNX1 Antikörper) and SNX2 play interchangeable but essential roles.
study indicates that hVps34 (zeige PIK3C3 Antikörper) and its product PI(3 (zeige PI3 Antikörper))P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 (zeige SNX4 Antikörper) are likely to be effectors in this pathway
BLOS1 (zeige BLOC1S1 Antikörper) interacts with sorting nexin 2 and the ESCRT-I (zeige VPS28 Antikörper) component TSG101 (zeige TSG101 Antikörper) to mediate the sorting of EGFR (zeige EGFR Antikörper) into endosomal compartments
Data show that mice lacking sorting nexin 1 (zeige SNX1 Antikörper) or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1 (zeige SNX1 Antikörper)), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 (zeige SNX1 Antikörper) in retromer activity during embryonic development.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.
sorting nexin 2
, sorting nexin-2
, sorting nexin-2-like
, transformation-related gene 9 protein