Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteine (SLC9A3R2)

SLC9A3R2 encodes a member of the NHERF family of PDZ scaffolding proteins. Zusätzlich bieten wir Ihnen Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Antikörper (75) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC9A3R2 9351 Q15599
SLC9A3R2 65962 Q9JHL1
SLC9A3R2 116501 Q920G2
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Top Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteine auf antikoerper-online.de

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$682.00
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,847.17
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,911.33
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SLC9A3R2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartnern

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins.

  2. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin is unaffected by S303D

  3. Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCdelta signaling.

  4. Data indicate that the tails promote different microvillar localizations for EBP50 and E3KARP, which localized along the full length and to the base of microvilli, respectively.

  5. Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 sequence. The PDZ1-LPA2 binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions.

  6. NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3

  7. functional regulation of C3aR by NHERFs in human mast cells

  8. AnxA2 and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site.

  9. NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling.

  10. CaMKII inhibition of NHE3 reguires NHEF2.

  11. Data show that both NHERF2 and NHERF1 are involved in setting NHE3 activity.

  12. MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

  13. The results of this study revealed that NHERF-2 can interact with GLAST in astrocytes to enhance GLAST stability and activity.

  14. WNK4 and NHERF2 synergistically regulate TRPV5 by enhancing its forward trafficking and increasing its stability at plasma membrane, respectively.

  15. The authors generated a HeLa cell line stably expressing HA-tagged NHERF2 and found that Map, EspI and NleH1 colocalize and interact with intracellular NHERF2 via their C-terminal PDZ-binding motif.

  16. Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells.

  17. NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation.

  18. Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

  19. E3KARP has a restricted tissue distribution with the highest expression being found in lung. It is largely colocalized with moesin and radixin, especially in the alveoli of the lung, as well as being highly enriched in the renal corpuscle.

  20. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.

Cow (Bovine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. the essential role of NHERF2 in endothelial cell adhesion/migration and angiogenesis. [NHERF2]

Pig (Porcine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Analysis showed that SLC9A3R2 gene has the closest genetic relationship with the SLC9A3R2 gene of human; it is structured in 7 exons and 6 introns; tissue expression analysis indicated that SLC9A3R2 gene is differentially expressed in different tissues.

Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Protein Überblick

Protein Überblick

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit SLC9A3R2

  • SLC9A3 regulator 2 (SLC9A3R2)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (Slc9a3r2)
  • SLC9A3 regulator 2 (Slc9a3r2)
  • SLC9A3 regulator 2 S homeolog (slc9a3r2.S)
  • 0610011L07Rik Protein
  • 1200011K07Rik Protein
  • 2010007A20Rik Protein
  • E3karp Protein
  • NHE3RF2 Protein
  • nherf-2 Protein
  • nherf2 Protein
  • Octs2 Protein
  • Sip-1 Protein
  • Sip1 Protein
  • slc9a3r2 Protein
  • Sryip1 Protein
  • Tka-1 Protein

Bezeichner auf Proteinebene für SLC9A3R2

NHE3 kinase A regulatory protein E3KARP , NHE3 regulatory factor 2 , Na(+)/H(+) exchange regulatory cofactor NHE-RF2 , SRY-interacting protein 1 , sodium/hydrogen exchanger 3 kinase A regulatory protein , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 , solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 , solute carrier family 9 isoform A3 regulatory factor 2 , tyrosine kinase activator protein 1 , solute carrier family 9 isoform 3 regulator 2 , PDZ domain containing protein NHERF-2 , PDZ domain-containing protein NHERF-2 , sodium-hydrogen exchanger regulatory factor 2 , Sry interacting protein 1 , sodium/hydrogen exchanger , solute carrier family 9 isoform 3 regulator 2, isoform A; sodium/hydrogen exchanger , NHERF-2 , SIP-1 , TKA-1 , NHE3 kinase A regulatory protein 2 , SLC9A3 regulator 2 S homeolog , solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 S homeolog

GENE ID SPEZIES
9351 Homo sapiens
416550 Gallus gallus
479884 Canis lupus familiaris
694658 Macaca mulatta
768005 Bos taurus
100008813 Oryctolagus cuniculus
100192448 Sus scrofa
65962 Mus musculus
116501 Rattus norvegicus
100731241 Cavia porcellus
399076 Xenopus laevis
Ausgewählte Anbieter für Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteine (SLC9A3R2)
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