Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Proteine (Slc7a7)

The protein encoded by Slc7a7 is the light subunit of a cationic amino acid transporter. Zusätzlich bieten wir Ihnen Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Antikörper (21) und Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Slc7a7 9056 Q9UM01
Ratte Slc7a7 Slc7a7 83509 Q9R0S5
Maus Slc7a7 Slc7a7 20540 Q9Z1K8
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Slc7a7 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 (Slc7a7) Interaktionspartnern

Human Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 (Slc7a7) Interaktionspartner

  1. SLC7A7 overexpression decreased the apoptosis rate, increased the proportion of cells in the G1 phase, decreased the proportion of G2 cells, and significantly increased cell migration and invasion and increased intracellular arginine would activate mTOR, and induce apoptosis in SLC7A7 knockdown Jurkat cells.

  2. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia.

  3. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide.

  4. The study reports a significant association between SLC7A7 rs12436190 and the risk of glioma in a Chinese population.

  5. the 1471 delTTCT mutation was identified in exon 9 in the homozygous state for all Tunisian patients with lysinuric protein Intolerance; The 1471 deITTCT mutation seems to be a common mutation of Tunisian population

  6. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations

  7. SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population.

  8. SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients

  9. SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance.

  10. during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased

  11. novel SLC7A7 mutations in patients with lysinuric protein intolerance

  12. expression levels and putative 5' promoter elements of the SLC7A7 gene

  13. putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance

  14. mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance

  15. identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression

  16. Mutation in the SLC7A7 gene is associated with lysinuric protein intolerance

  17. A review of the current knowledge of SLC7A7 mutations and their role in LPI pathogenesis.

  18. results suggest genomic rearrangement of SLC7A7 play more important role in lysinuric protein intolerance than has been reported; 3' region AluY repeat could be a recombination hot spot as it is involved in 38% of SLC7A7 rearranged chromosomes described

Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 (Slc7a7) Protein Überblick

Protein Überblick

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Slc7a7

  • solute carrier family 7 member 7 (SLC7A7)
  • solute carrier family 7 member 7 (Slc7a7)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 (Slc7a7)
  • AI790233 Protein
  • LAT3 Protein
  • LPI Protein
  • MOP-2 Protein
  • my+lat1 Protein
  • y+LAT-1 Protein
  • y+LAT1 Protein

Bezeichner auf Proteinebene für Slc7a7

Y+L amino acid transporter 1 , monocyte amino acid permease 2 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 , y(+)L-type amino acid transporter 1 , solute carrier family 7 member 7 , y+LAT-1 , y+LAT1

GENE ID SPEZIES
9056 Homo sapiens
83509 Rattus norvegicus
20540 Mus musculus
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