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SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Zusätzlich bieten wir Ihnen SLC7A11 Antikörper (101) und SLC7A11 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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System xC(-)-mediated TrkA (zeige NTRK1 ELISA Kits) activation therefore presents a promising target for therapeutic intervention in cancer pain treatment.
High expression of cystine-glutamate (zeige GRIN1 ELISA Kits) antiporter SLC7A11 is associated with advanced pathological stages of liver carcinoma. SLC7A11 overexpression is a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma.
the level of antisense SLC7A11 was markedly reduced in epithelial ovarian cancer tissues and cell lines compared with those of normal control; reduction of antisense SLC7A11 level prompted ovarian cancer cell migration mainly by suppressing the expression of SLC7A11
CD44v9 in tumor specimens has potential as a novel indicator for identifying a cisplatin-chemoresistant population among urothelial cancer patients. CD44v8-10 contributes to reactive oxygen species defenses, which are involved in chemoresistance, by promoting the function of xCT, which adjusts the synthesis of glutathione.
Oncogenic PIK3CA (zeige PIK3CA ELISA Kits) alters methionine and cysteine utilization, partly by inhibiting xCT to contribute to the methionine dependency phenotype in human breast cancer cells.
these observations suggest that SLC7A11 may be a vital biomarker for the diagnosis and prognosis in human laryngeal squamous cell carcinoma (LSCC) and targeting SLC7A11 appears to be a potentially significant method for LSCC treatment.
Aberrant neuronal or neuroendocrine system may be involved in the suppressed reproductive performance in xCT deficient male mice.
overexpression of SLC7A11 in the context of glioblastoma multiforme may contribute to tumor progression.
miR (zeige MLXIP ELISA Kits)-375 served as a tumor suppressor via regulating SLC7A11.
As targets of oncogenes with intrinsic tyrosine kinase (zeige TXK ELISA Kits) activity, STAT3 (zeige STAT3 ELISA Kits) and STAT5 (zeige STAT5A ELISA Kits) become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT expression. (Review)
In mouse brain parenchyma, xCT is selectively expressed in scattered astrocytes throughout the brain. Especially strong xCT labeling is found in select blood/brain/CSF (zeige CSF2 ELISA Kits) interface areas: in the leptomeninges, along larger blood vessels, in some circumventricular organs and in tanycytes in parts of the walls of the ventral third ventricle. Study did not find expression of xCT in microglia, oligodendrocytes and neurons.
Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb) through TLR2/Akt (zeige AKT1 ELISA Kits)- and p38 (zeige CRK ELISA Kits)-dependent signaling pathway.
Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis.
Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate (zeige GRIN1 ELISA Kits) toxicity.
ARF inhibits tumor growth by suppressing the ability of NRF2 (zeige NFE2L2 ELISA Kits) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (zeige GRIN1 ELISA Kits) antiporter that regulates reactive oxygen species (ROS (zeige ROS1 ELISA Kits))-induced ferroptosis.
Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.
Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (zeige GRIN1 ELISA Kits), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (zeige GRIN1 ELISA Kits), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.
HIF-1alpha (zeige HIF1A ELISA Kits) plays a role in cerebral ischaemia-reperfusion -induced glutamate (zeige GRIN1 ELISA Kits) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (zeige GRIN1 ELISA Kits) outflow
Results provided important insights into understanding the mechanism associated with xCT deficiency.
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
, cystine/glutamate transporter
, solute carrier family 7, member 11
, Cystine/glutamate transporter
, cystine/glutamate transporter-like
, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
, amino acid transport system xc-
, calcium channel blocker resistance protein CCBR1
, solute carrier family 7 member 11
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
, cysteine/glutamate transporter
, sodium independent anionic amino acid transport system