anti-Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) Antikörper

SLC6A2 encodes a member of the sodium symporter family. Zusätzlich bieten wir Ihnen SLC6A2 Kits (26) und SLC6A2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC6A2 6530 P23975
SLC6A2 20538 O55192
SLC6A2 83511  
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Top anti-SLC6A2 Antikörper auf

Showing 10 out of 50 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SLC6A2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human heart Host:  Rabbit  Target Name:  SLC6A2  Sample Tissue:  Human Fetal Liver  Antibody Dilution:  1.0ug/ml 100 μL 2 bis 3 Tage
Rind (Kuh) Kaninchen Unkonjugiert IC, IF, IP, WB Immunofluorescent analysis of NET (pS357) staining in HUVEC cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of NET (pS357) expression in HUVEC PMA-treated (A), HT29 PMA-treated (B) whole cell lysates. 200 μL 13 bis 14 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Verfügbar
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μL 11 bis 14 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using SLC6A2 antibody. 100 μL 11 bis 13 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC (p), WB 200 μL 12 bis 14 Tage
Human Kaninchen Unkonjugiert ELISA, IF   100 μL Verfügbar
Human Kaninchen Unkonjugiert ELISA, WB 100 μL 2 bis 3 Tage
Ratte Kaninchen Unkonjugiert ELISA, WB   100 μg 11 bis 14 Tage

Am meisten referenzierte anti-SLC6A2 Antikörper

  1. Cow (Bovine) Polyclonal SLC6A2 Primary Antibody für WB - ABIN2777051 : Suzuki, Matsumoto, Oshino, Kamata, Goto, Otani: Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females. in Neuroscience letters 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SLC6A2 Primary Antibody für CM, ICC - ABIN2746956 : Wersinger, Jeannotte, Sidhu: Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein. in The European journal of neuroscience 2007 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen SLC6A2 Interaktionspartner

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) Interaktionspartner

  1. Using RNA of isolated chromatin combined with massive parallel sequencing (RICh-seq) we show that let-7i miRNA suppresses NET by methyl-CpG-binding protein 2 (MeCP2)

  2. A SNP in the NET gene in patients with resistant hypertension is associated with higher plasma noradrenaline concentration and elevated SBP. Impaired NET function may be a contributor to the pronounced activation of the sympathetic nervous system characteristic of patients with resistant hypertension.

  3. Study shows a functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.

  4. Pharmacogenetic association analyses of the norepinephrine transporter (NET, SLC6A2) gene in methylphenidate response among Hungarian Attention Deficit Hyperactivity Disorder (ADHD) children pointed to the possible involvement of the promoter - 3081 A/T SNP (rs28386840), which was supported by a meta-analysis combining our results using Central-European ADHD population with published data of Korean ADHD samples.

  5. Study finds that ketamine influences the locus coeruleus norepinephrine network, with a dependency on norepinephrine transporter genotype.

  6. Our case-control study and meta-analysis suggest that the NET gene G1287A polymorphism may not be involved in the etiology of schizophrenia in the Chinese Han population

  7. genetic association/pharmacogenetic studies in population in Switzerland: Data from controlled studies suggest that SNPs in SLC6A2 (rs1861647, rs2242446, rs36029) weakly moderate acute cardiovascular response to MDMA (methylenedioxymethamphetamine, "ecstasy") and may play minor role in adverse cardiovascular events when MDMA is used recreationally.

  8. Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.

  9. case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 and DRD2 in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls

  10. nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed.

  11. T allele of the SNP rs7194256 in the 3'UTR of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations

  12. Polymorphisms of COMT (c.649G>A), MAO-A (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease

  13. NET rs2242446/T-182C may serve as a biomarker to predict the likelihood of remission with venlafaxine in older adults with major depression. These findings may help to optimize antidepressant outcomes in older adults.

  14. These results suggest that NET polymorphism may affect the SNRI response in Korean panic disorder patients.

  15. Imaging genetic study showed significant differences in NET nondisplaceable binding potential in patients with attention deficit hyperactivity disorder compared to healthy controls, depending on their genotype

  16. NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.

  17. In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

  18. This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety

  19. Study identified the haplotype rs36011 (T)/rs1566652 (G) as a novel genetic marker involved in both attention-deficit/hyperactivity disorder disease susceptibility and visual memory

  20. a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) Interaktionspartner

  1. Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach

  2. inhibition of p38 MAPK or the manipulation of NET-Thr(30) motif/phosphorylation via a TAT peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference

  3. this is the first report which suggests the beneficial effect of modulation of TRPV1 receptors and NET in Chronic cerebral hypoperfusion vascular dementia

  4. daily sympathetic activation induced by mild chronic stress was unable to induce bone loss, unless NET activity was blocked.

  5. NET dysfunction is sufficient to produce a postural orthostatic tachycardia syndrome phenotype.

  6. Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter.

  7. NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons.

  8. propose that amplified norepinephrine transporter function in rictor KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron

  9. Report a protocol to monitor NET transport rate at the level of the single nerve terminal varicosity using a fluorescent substrate.

  10. We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation.

  11. Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase, dopamine transporter and norepinephrine transporter expression.

  12. NET function may be a physiologically relevant regulatory element in embryonic development.

  13. NET deficiency increases extraneuronal levels of NE, dopamine, & epinephrine. The impact of this hyperadrenergic state is greatest in the periphery & is manifested by high blood pressure & excessive tachycardia with wakefulness & physical activity.

  14. this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains

  15. Knockout mice showed enhanced binding of the selective alpha(2)drenergic antagonist [(3)H]RX821002 in several brain regions

  16. The effects of DAT KO in animal models of depression are larger than those produced by NET or SERT KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity.

  17. a novel triple mutation that retains close to wild-type transport function but displays a 37-fold decrease in cocaine sensitivity and 24-fold decrease in desipramine sensitivity.

  18. Data further suggest deregulation of signaling pathways in the development and/or function of the NET-deficient peripheral, central and enteric nervous systems.

  19. conditioned locomotion was not observed in DAT KO mice, and was reduced in SERT KO and NET KO mice.

  20. resistance of the NET KO mice to the stress-induced depression-associated behaviors and biochemical changes highlight the importance of noradrenergic pathways in the maintenance of mood

SLC6A2 Antigen-Profil

Protein Überblick

This gene encodes a member of the sodium symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Genbezeichner und Symbole assoziert mit SLC6A2

  • solute carrier family 6 member 2 (SLC6A2) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (Slc6a2) Antikörper
  • solute carrier family 6 member 2 (Slc6a2) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2) Antikörper
  • solute carrier family 6 member 5 (SLC6A5) Antikörper
  • NAT1 Antikörper
  • NE-T Antikörper
  • Net Antikörper
  • NET1 Antikörper
  • SLC6A2 Antikörper
  • Slc6a5 Antikörper

Bezeichner auf Proteinebene für SLC6A2

neurotransmitter transporter , norepinephrine transporter , sodium-dependent noradrenaline transporter , solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 , solute carrier family 6 member 5 , NE transporter , solute carrier family 6 member 2 , NaCl-dependent norepinephrine transporter , neurotransmitter transporter, noradrenal , transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157 , NET , norepinephrine plasma membrane transporter , pulmonary norepinephrine plasma membrane transporter , sodium-dependent noradrenaline transporter-like , sodium- and chloride-dependent glycine transporter 2-like , solute carrier family 6 (neurotransmitter transporter, glycine), member 5

6530 Homo sapiens
20538 Mus musculus
83511 Rattus norvegicus
395458 Gallus gallus
282363 Bos taurus
443100 Ovis aries
454096 Pan troglodytes
487272 Canis lupus familiaris
100061346 Equus caballus
100388661 Callithrix jacchus
100465372 Ailuropoda melanoleuca
100521246 Sus scrofa
100598446 Nomascus leucogenys
100723578 Cavia porcellus
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