Solute Carrier Family 25, Member 27 Proteine (SLC25A27)

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Zusätzlich bieten wir Ihnen SLC25A27 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC25A27 9481 O95847
Maus SLC25A27 SLC25A27 74011  
Ratte SLC25A27 SLC25A27 85262  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
$284.90
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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SLC25A27 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Solute Carrier Family 25, Member 27 (SLC25A27) Interaktionspartnern

Human Solute Carrier Family 25, Member 27 (SLC25A27) Interaktionspartner

  1. This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease.

  2. UCP4 mRNA of cartilage tissues was decreased in osteoarthritis patients, which was negatively correlated with synovial fluid (SF) leptin (zeige LEP Proteine) concentration.

  3. Compares and contrasts all the known human SLC25A (zeige SLC25A25 Proteine)* genes and includes functional information.

  4. UCP4 is a target effector gene of the NF-kappaB (zeige NFKB1 Proteine) c-Rel (zeige NFkBP65 Proteine) prosurvival pathway to mitigate the effects of oxidative stress.

  5. Neuronal UCP4 exhibits transmembrane chloride transport activity.

  6. Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II.

  7. UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor (zeige PGR Proteine) expression, and positivity for p53 (zeige TP53 Proteine) and Ki-67 (zeige MKI67 Proteine) in breast carcinomas.

  8. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.(

  9. the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia.

  10. has a significant role in NF-kappaB (zeige NFKB1 Proteine)-mediated prosurvival signaling and cell protection against neurotoxins

Mouse (Murine) Solute Carrier Family 25, Member 27 (SLC25A27) Interaktionspartner

  1. UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.

  2. astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival

  3. UCP2 (zeige UCP2 Proteine) is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells

  4. Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA (zeige TFAM Proteine).

  5. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

SLC25A27 Protein Überblick

Protein Überblick

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SLC25A27

  • solute carrier family 25 member 27 (SLC25A27)
  • solute carrier family 25, member 27 (Slc25a27)
  • 3632410G24Rik Protein
  • 9430092A03Rik Protein
  • D530043E16Rik Protein
  • Ucp4 Protein

Bezeichner auf Proteinebene für SLC25A27

UCP 4 , mitochondrial uncoupling protein 4 , uncoupling protein 4 , uncoupling protein UCP-4

GENE ID SPEZIES
9481 Homo sapiens
609887 Canis lupus familiaris
100157774 Sus scrofa
74011 Mus musculus
85262 Rattus norvegicus
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