Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) ELISA Kits

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) Interaktionspartner

1. African-specific promoter polymorphisms can cause a decrease in the SLC22A2 gene expression levels in vitro, which in turn, may influence the pharmacokinetic profiles of cationic drugs.

2. OCT2-altered expression in primary and metastatic cancer cells.

3. Circ2174 has sequence complementarity to miR149 which can target Oct-2.These data suggest a mechanism whereby circ2174 can act as a sponge to regulate the expression of miR149, and thereby modulate Oct-2 and interleukin-16 signaling pathways in cholangiocarcinoma.

4. SLC22A2 deletion is associated with motor speech disorders, and language delays.

5. inhibitory potency for morphine uptake was affected by the OCT1*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism

6. Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.

7. The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102.

8. This study of SLC22A2 contributes in filling the gap that exists with regards to genetic information about important variations in organic cation transporter genes for the indigenous populations of South Africa.

9. we assessed the role of miR-21 in mediating renal cell carcinoma chemoresistance and further showed that miR-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 platinum influx transporter expression

10. Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers

11. Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney.

12. OCT2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.

13. An association was found between SNPs in OCT2 transporter and lack of metformin response in type 2 diabetes mellitus patients.

14. Seventeen of the variants observed in the SLC22A2 gene of the Xhosa population were specific to/or occurred at a higher frequency in African populations or populations with a recent connection to the African continent.

15. We noted a statistically significant association between the nonsynonymous SNP rs316019(SLC22A2) and cisplatin-induced ototoxicity, in that the T allele occurred more frequently in patients who experienced no ototoxicity from cisplatin treatment.

16. the loss-of-function variant OCT2-T201M (rs145450955) contribute to changes in insulin resistance and beta cell activity in patients with T2D treated with metformin.

17. The 808G>T variant of SLC22A2 improves the metformin long-term glucose-lowering effect in Chinese type 2 diabetics.

18. functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2

19. Findings suggest specific involvement of each organic cation transporters (OCT1-3) in drug transportation.

20. The functional OCT2 Ser270Ala polymorphism is significantly associated with abstinence among treatment-seeking smokers.

Mouse (Murine) Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) Interaktionspartner

1. Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes

2. we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2

3. Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.

4. Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.

5. Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours.

6. findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.

7. Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.

8. OCT1 and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP and MPTP-induced dopaminergic toxicity in rodents.

9. a comparison of the transport properties of Oct2 and Oct1

10. This study shows that Oct1 and Oct2 together are essential for renal secretion of (small) organic cations.

11. The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.

12. adenovirus produced an increase in OCT-2 levels along with increased cellular OCT-2 steady-state mRNA in lung epithelial cells; results indicate that adenoviruses can disrupt choline trafficking in lung epithelia by upregulating expression of OCT-2

13. Doubling of airway epithelial acetylcholine (ACh) in OCT1/2-/- mice is consistent with OCT1 and/or 2 mediating ACh release from respiratory epithelium. This effect does not contribute to 5-HT-induced constriction of murine intrapulmonary bronchi.

14. demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations

15. Deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels. The Oct1/Oct2-deficient mice were protected from severe cisplatin-induced renal tubular damage.

Cow (Bovine) Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) Interaktionspartner

1. OCTN2 expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.

2. Gene expression of the carnitine transporter OCTN2 and carnitine transport are regulated by PPARbeta/delta in bovine cells.