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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Zusätzlich bieten wir Ihnen Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antikörper (52) und Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (zeige KCNK3 Proteine)/OAT3.
The putative promoter sequences from hOAT1 (SLC22A6 (zeige SLC22A6 Proteine)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
PPIs inhibit [(3)H]MTX (zeige MTX1 Proteine) transport via hOAT3 inhibition.
The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
Pemetrexed is a superior substrate to methotrexate for hOAT3.
In HEK293-Flp (zeige HPD Proteine)-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].
The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.
transport of xanthurenic acid by OAT1 (zeige KCNK3 Proteine) and OAT3
Both hOAT1 (zeige SLC22A6 Proteine) and hOAT3 markedly stimulated the uptake of kynurenic acid into oocytes.
OAT1 (zeige SLC22A6 Proteine) plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (zeige SLC22A6 Proteine) and OAT3).
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
At the protein level, mOat3 and mOat1 (zeige SLC22A6 Proteine) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (zeige SLC22A6 Proteine) is male dominant due to androgen stimulation.
The results are consistent with a contribution of OAT3 and possibly OAT1 (zeige SLC22A6 Proteine) to renal creatinine secretion in mice.
DAT (zeige SLC6A3 Proteine) and Oct3 (zeige POU5F1 Proteine) modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling
functional differences in the relative importance of OAT1 (zeige SLC22A6 Proteine) and OAT3 in antiviral handling in developing and mature tissue
the ontogenic pattern of expression of OAT1 (zeige SLC22A6 Proteine) and OAT3 in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus
Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter)
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
, organic anion transporter 3
, solute carrier family 22 member 8
, reduced in osteosclerosis transporter
, solute carrier family 22, member 8
, solute carrier family 22 ,member 8
, renal organic anion transporter 3