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A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 (zeige SLC22A12 Antikörper) and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level.
I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans.
Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.
Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier (zeige SERTAD2 Antikörper) family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients.
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males.
NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.
NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review]
We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups.
Renal urate transporter (zeige LGALS9 Antikörper) SLC17A1 is the third locus associated with gout at a genome-wide level of significance.
results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
Data show that hepatocyte nuclear factor 1 alpha (HNF1alpha (zeige HNF1A Antikörper)) directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation.
Subtype switching of vesicular glutamate (zeige GRIN1 Antikörper) transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
Mossy terminals are immunoreactive for VGLUT1 and mGluR1alpha dendritic brushes are immunopositive for VGLUT1 in organotypic cultures of mouse vestibulocerebellum.
The finding of VGLUT1 immunoreactivity in motor endplates of striated (zeige NSDHL Antikörper) esophageal but not skeletal muscles may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated (zeige NSDHL Antikörper) muscle fibers.
apical Na-P(i) type I activity is increased at the onset of ATP depletion in medullary thick ascending limb cells.
cotransports sodium and phosphate
Na(+)/PI cotransporter 1
, renal Na(+)-dependent phosphate cotransporter 1
, renal sodium-dependent phosphate transport protein 1
, renal sodium-phosphate transport protein 1
, sodium phosphate transporter
, sodium-dependent phosphate transport protein 1
, sodium/phosphate cotransporter 1
, sodium/phosphate type I cotransporter
, solute carrier family 17 (sodium phosphate), member 1
, solute carrier family 17 (vesicular glutamate transporter), member 1
, solute carrier family 17 member 1
, solute carrier family 17 vesicular glutamate transporter), member 1
, sodium-dependent phosphate/anion cotransporter
, solute carrier family 17 (sodium/hydrogen exchanger), member 1
, renal cortical Na/P-i-cotransporter