anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antikörper

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus SCN3A SCN3A 20269  
Anti-Ratte SCN3A SCN3A 497770 P08104
Anti-Human SCN3A SCN3A 6328 Q9NY46
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Top anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 43 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged SCN3A is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Anti-SCN3A / Nav1.3 antibody  ABIN1049321 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Anti-SCN3A / Nav1.3 antibody  ABIN1049320 IHC staining of human spinal cord. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC (p) 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$685.40
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of 293T and HT-1080 cells, using SCN3A antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Maus Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
Details
Human Kaninchen Unkonjugiert ELISA, IF, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$532.07
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: SCN3A Antibody [NBP2-34003] - cerebellum Immunohistochemistry-Paraffin: SCN3A Antibody [NBP2-34003] - Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in neurons. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Ratte Kaninchen Unkonjugiert IHC, WB   50 μL Anmelden zum Anzeigen 11 bis 16 Tage
$726.00
Details

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type III, alpha Subunit Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Interaktionspartner

  1. Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp (zeige PHEX Antikörper) mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.

  2. Scn3a was mapped to the QTL for febrile seizure susceptibility.

  3. a huge difference in electrophysiological function between SCN1A (zeige SCN1A Antikörper) and SCN3A mutations in the pore region; this might explain the more common SCN1A (zeige SCN1A Antikörper) mutations detected in patients with epilepsy and the more severe phenotypes associated with these mutations

  4. these findings suggest that CpG methylation and MBD2 (zeige MBD2 Antikörper) are involved in altering Scn3a expression during postnatal development and seizure condition.

  5. These results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression.

  6. These data demonstrate that Nav1.3 is neither necessary nor sufficient for the development of nerve-injury related pain.

  7. SCN2A (zeige SCN2A Antikörper), SCN3A, and SCN9A (zeige SCN9A Antikörper) are expressed beneath tight junctions in subsets of taste cells. SCN3A and SCN9A (zeige SCN9A Antikörper) are expressed in TRPM5 (zeige TRPM5 Antikörper) cells, while SCN2A (zeige SCN2A Antikörper) was expressed in TRPM5 (zeige TRPM5 Antikörper) and PKD2L1 (zeige PKD2L1 Antikörper) cells.

Human Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Interaktionspartner

  1. Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp (zeige PHEX Antikörper) mice display increased seizure susceptibility, hypoactivity, and impaired motor learning.

  2. sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 (zeige SOD1 Antikörper) protein

  3. Data indicate eight new cases with overlapping duplications at 2q24 and SCN3A was not involved in duplication, suggesting that having an extra copy of SCN2A (zeige SCN2A Antikörper) has an effect on epilepsy pathogenesis.

  4. Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy.

  5. Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A (zeige SCN1A Antikörper), SCN2A (zeige SCN2A Antikörper), and SCN3A genes with drug responsiveness in epilepsy.

  6. This study demonistrated that associated with a duplication of the SCN2A (zeige SCN2A Antikörper) and SCN3A gene cluster on 2q24 in patient with early onset epilepsy.

  7. Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb.

  8. Deletions in SCN3A gene is associated with autistic features and developmental delay.

  9. In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 (zeige SCN9A Antikörper) and an increase in the expression of Nav1.3, Nav1.8 (zeige SCN10A Antikörper) expression not significantly different; TN can be, at least in part, a channelopathy.

  10. in autism families, two polymorphic coding variants of SCN3A are described

Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Antigen-Profil

Protein Überblick

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SCN3A

  • sodium voltage-gated channel alpha subunit 3 (SCN3A) Antikörper
  • sodium channel, voltage gated, type III alpha subunit (scn3a) Antikörper
  • sodium channel protein type 9 subunit alpha (LOC100180733) Antikörper
  • sodium channel, voltage-gated, type III, alpha (Scn3a) Antikörper
  • sodium voltage-gated channel alpha subunit 3 (Scn3a) Antikörper
  • sodium channel protein type 3 subunit alpha (LOC534223) Antikörper
  • Gm1000 Antikörper
  • NAC3 Antikörper
  • Nav1.3 Antikörper
  • SCIII Antikörper
  • Scn2a Antikörper
  • SCN3A Antikörper

Bezeichner auf Proteinebene für SCN3A

sodium channel, voltage-gated, type III, alpha subunit , sodium channel, voltage-gated, type III, alpha polypeptide , sodium channel protein brain III subunit alpha , sodium channel protein type 3 subunit alpha , sodium channel protein type III subunit alpha , sodium channel protein, brain III subunit alpha , sodium channel, voltage-gated, type 3, alpha subunit , voltage-gated sodium channel subtype III , voltage-gated sodium channel subunit alpha Nav1.3 , brain III voltage-gated sodium channel , voltage-dependent sodium channel SCN3A

GENE ID SPEZIES
459699 Pan troglodytes
478772 Canis lupus familiaris
100125099 Xenopus (Silurana) tropicalis
100180733 Ciona intestinalis
20269 Mus musculus
497770 Rattus norvegicus
6328 Homo sapiens
424180 Gallus gallus
534223 Bos taurus
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