Sodium Channel, Nonvoltage-Gated 1, delta Proteine (SCNN1D)

Human Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) Interaktionspartner

1. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations

2. deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.

3. delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption

4. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins

5. delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels.

6. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination.

7. Identify the specific domains of epithelial sodium channels that are responsible for the differences in the response to flow of alphabetagamma and deltabetagamma channels.

8. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition.

9. CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC.

10. Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel.

11. delta ENaC is regulated by Murr1

12. ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain

13. ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism

14. the interactions of delta-ENaC with alpha beta gamma-human epithelial sodium channel subunits could account for heterogeneity of native epithelial channels

15. analysis of anovel spliced variant of the ENaC delta-subunit in the human brain

16. ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei.

17. Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques.

18. EIPA [5-(N-ethyl-N-isopropyl)-amiloride hydrochloride] inhibition of ENaCs, possibly ENaC-alpha and ENaC-delta, significantly improved the sperm motility in healthy donors and in asthenospermia patients.

19. ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease

20. Regulation of epithelial sodium channels by cGMP/PKGII.