Small VCP/p97-Interacting Protein Proteine (SVIP)

Human Small VCP/p97-Interacting Protein (SVIP) Interaktionspartner

1. overexpression of gp78 or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin deficiency

2. the interactions between P97 and these motifs, including VCP-binding motif (VBM) and VCP-interacting motif (VIM). The solution structures of the VBM motif from HRD1 and the VIM motif from SVIP are both comprised mainly of a single alpha-helix.

3. A major portion of SVIP is intrinsically disordered in solution.

4. SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy.

5. SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex.

Mouse (Murine) Small VCP/p97-Interacting Protein (SVIP) Interaktionspartner

1. SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies.

2. SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy.