Small VCP/p97-Interacting Protein Proteine (SVIP)

Human Small VCP/p97-Interacting Protein (SVIP) Interaktionspartner

1. overexpression of gp78 (zeige AMFR Proteine) or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (zeige SERPINA1 Proteine) deficiency

2. the interactions between P97 (zeige EIF4G2 Proteine) and these motifs, including VCP (zeige vcp Proteine)-binding motif (VBM) and VCP (zeige vcp Proteine)-interacting motif (VIM (zeige VIM Proteine)). The solution structures of the VBM motif from HRD1 (zeige SYVN1 Proteine) and the VIM (zeige VIM Proteine) motif from SVIP are both comprised mainly of a single alpha-helix.

3. A major portion of SVIP is intrinsi (zeige vcp Proteine)cally disordered in solution.

4. SVIP plays a regulatory role in p97 (zeige EIF4G2 Proteine) subcellular localization and is a novel regulator of autophagy.

5. SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78 (zeige AMFR Proteine)-p97/VCP (zeige vcp Proteine)-Derlin1 (zeige DERL1 Proteine) complex.

Mouse (Murine) Small VCP/p97-Interacting Protein (SVIP) Interaktionspartner

1. SVIP and valosin containing protein (zeige vcp Proteine) were seen to be co-localized in neuronal cell bodies.

2. SVIP plays a regulatory role in p97 (zeige EIF4G2 Proteine) subcellular localization and is a novel regulator of autophagy.