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Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.. Zusätzlich bieten wir Ihnen SVIP Kits (6) und und viele weitere Produktgruppen zu diesem Protein an.
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overexpression of gp78 or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin deficiency
the interactions between P97 and these motifs, including VCP-binding motif (VBM) and VCP-interacting motif (VIM). The solution structures of the VBM motif from HRD1 and the VIM motif from SVIP are both comprised mainly of a single alpha-helix.
A major portion of SVIP is intrinsically disordered in solution.
SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy.
SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex.
SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies.
Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.