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SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs.
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Human Polyclonal SIM2 Primary Antibody für ELISA, WB - ABIN562879
Zhang, Xu, Cao, Wei, Yang, Uzan, Peng: Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. in Cell stress & chaperones 2010
Cow (Bovine) Polyclonal SIM2 Primary Antibody für WB - ABIN2780639
Laffin, Wellberg, Kwak, Burghardt, Metz, Gustafson, Schedin, Porter: Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. in Molecular and cellular biology 2008
Show all 2 Pubmed References
Mouse (Murine) Polyclonal SIM2 Primary Antibody für ELISA, WB - ABIN4353807
Fei, Wu, Zhou, Wang, Wang, Yin, Wang, Qiu: [Association study of SIM2 gene polymorphisms with susceptibility to congenital scoliosis in a Chinese Han population]. in Zhonghua yi xue za zhi 2010
SIM2 increases CRT (zeige SLC6A8 Antikörper) sensitivity through tumor differentiation by cooperation with ARNT (zeige ARNT Antikörper).
Two genes, OR51E2 (zeige OR51E2 Antikörper) and SIM2, and two miRNAs, miR (zeige MLXIP Antikörper)-200c and miR (zeige MLXIP Antikörper)-200b, showed significant association with prostate cancer.
In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells.
a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 (zeige CD4 Antikörper) and CD8 (zeige CD8A Antikörper) T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers.
Data showed that SIM2 was highly expressed in human glioma tumors and cell lines and its short form might increase the invasion of glioma cells through the alteration of epithelial-mesenchymal transition.
Data suggest selected SIM1 (zeige SIM1 Antikörper) variants exhibit poor dimerization with ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2 (zeige ARNT2 Antikörper)) and anomalous intracellular localization; data were used to predict spot in SIM1 (zeige SIM1 Antikörper)/SIM2 (residues 290-326) critical in function.
miR (zeige MLXIP Antikörper)-200a is downregulated in human glioma and inhibition of miR (zeige MLXIP Antikörper)-200a caused upregulation of SIM2-s in T98G cells and promoted their motility.
Altered expression of SIM2 and ETS2 (zeige ETS2 Antikörper) could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome.
These results suggest an involvement of SIM2 in key traits of prostate tumor cell biology.
Significantly lower frequency of SIM2 C-G haplotype (rs2073601-rs2073416) was noticed in individuals with Down syndrome (P value =0.01669) and their fathers (P value=0.01185)
Ethanol induced Sim2 expression in cerebral cortices of P7 Mice via the PKA pathway.
Study provides evidence that SIM2 binds a specific set of enhancer elements thus explaining how SIM2 can regulate its gene network in neuronal features.
Our results establish that SIM2 is a crucial regulator in controlling expression of intestinal AMPs (zeige ADSL Antikörper)
Sim2 prevents entry into the myogenic program by repressing MyoD (zeige MYOD1 Antikörper) transcription during limb embryonic myogenesis.
mammary gland involution is disrupted in Sim2s overexpression and STAT3 (zeige STAT3 Antikörper)-mediated signaling and other pathways involved in the acute phase response are inhibited
Differential activities of murine single minded 1 (SIM1 (zeige SIM1 Antikörper)) and SIM2 on a hypoxic response element
Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity.
Data show that premature accumulation of hyaluronan in Sim2 -/- animal palates suggests a regulatory role for Sim2 in hyaluronan synthesis and in the establishment of craniofacial architecture.
Sim1 (zeige SIM1 Antikörper) and Sim2 act along compensatory, but not hierarchical, pathways, suggesting that they play similar roles in vivo.
Sim2 and Sim2s are isoforms that may play different roles during development or in tissue-specific effects on other protein-mediated pathways
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes
single-minded homolog 2
, class E basic helix-loop-helix protein 15
, single-minded homolog 2, short isoform
, transcription factor SIM2
, single-minded (Drosophila) homolog 2
, SIM transcription factor
, single-minded 2