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Histone acetylation plays a key role in the regulation of eukaryotic gene expression.
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In the nucleus, SLy2 (zeige SAMSN1 Antikörper) interacts with the SAP30/HDAC1 (zeige HDAC1 Antikörper) complex and regulates the activity of HDAC1 (zeige HDAC1 Antikörper).
The interaction domains between YY1 (zeige YY1 Antikörper) and SAP30 were mapped to the C-terminal segment of YY1 (zeige YY1 Antikörper) (295-414) and the C-terminal 91 amino acid region of SAP30.
The SAP30 gene may be involved in basal cell carcinogenesis.
PBF (zeige PTTG1IP Antikörper) binds to SAP30 and represses transcription via recruitment of the HDAC1 (zeige HDAC1 Antikörper) co-repressor complex
findings demonstrate new functions for SAP30L (zeige SAP30L Antikörper) and SAP30 by showing that they can associate directly with core histones as well as naked DNA
show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex for silencing ribosomal RNA genes
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
30 kDa Sin3-associated polypeptide
, Sin3 corepressor complex subunit SAP30
, Sin3-associated polypeptide, 30kDa
, histone deacetylase complex subunit SAP30
, sin3-associated polypeptide p30
, sin3-associated polypeptide, 30 kDa
, Sin3-associated protein
, sin3 associated polypeptide, 30kD
, sin3 corepressor complex subunit SAP30
, sin3-associated polypeptide, 30kDa
, sin3 associated polypeptide p30
, LOW QUALITY PROTEIN: histone deacetylase complex subunit SAP30
, Sin3A-associated protein