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High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation.
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the Slam locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (zeige CD244 Proteine). This effect is influenced by cytokines and leads to suppression of LFA-1 (zeige ITGAL Proteine) activity.
CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT (zeige CTSL1 Proteine) Cell Defects but Not T Follicular Helper Cell Defects.
We demonstrated that Bacille Calmette-Guerin infection significantly upregulated SLAMF1, which enhanced inflammatory response by activating the NF-kappaB (zeige NFKB1 Proteine) signaling pathway and facilitated bacterial clearance in BCG (zeige SLC11A1 Proteine)-infected RAW264.7 cells and mice.
Slamf1 and Slamf8 (zeige SLAMF8 Proteine) govern ROS (zeige ROS1 Proteine)-dependent innate immune responses of myeloid cells.
The combined effects of RIIB deletion and pathogenic SLAM can lead to severe lupus nephritis in the B6 genetic background.
SLAM-SAP (zeige APCS Proteine) signaling promotes differentiation of IL-17 (zeige IL17A Proteine)-producing T cells and progression of experimental autoimmune encephalomyelitis.
The goal of the current study was to determine whether Slam haplotype affected NKT (zeige CTSL1 Proteine) and Vgamma4+ T-cell responses subsequent to coxsackievirus b3 infection.
Signaling lymphocyte activation molecule regulates development of colitis in mice.
Slamf1, which controls phagosomal/lysosomal fusion and phagosomal NADPH-oxidase (zeige NOX1 Proteine) activity, is required for T.cruzi replication in macrophages and dendritic cells, but not in other cells, which do not express the receptor.
conclude that Slamf1 recruits a subset of Vps34 (zeige PIK3C3 Proteine)-associated proteins, which is involved in membrane fusion and NOX2 (zeige CYBB Proteine) regulation
CD150 and CD180 (zeige CD180 Proteine) receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels
this paper shows that the X-linked lymphoproliferative disease gene product SAP (zeige APCS Proteine) regulates signals induced through the co-receptor SLAM
combination of signals via CD150 and CD180 (zeige CD180 Proteine) leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed
EBF1 (zeige EBF1 Proteine) is critical for transcriptional control of SLAMF1 gene in human B cells.
MeV can hijack SLAMF1 to drive endocytosis using a complex pathway that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction. This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral attachment.
Malignant B-cell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform.
Data suggest that SLAMF1 is another significant piece in the intricate defective immune-regulatory function of patients with SLE.
results indicate that loss of SLAMF1 expression in chronic lymphocytic leukemia modulates genetic pathways
Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (zeige APCS Proteine) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM peptide.
High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
signaling lymphocyte activation molecule
, signaling lymphocytic activation molecule
, signaling lymphocytic activation molecule family member 1