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The protein encoded by SIRPB1 is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen Signal-Regulatory Protein beta 1 Antikörper (67) und Signal-Regulatory Protein beta 1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner.
SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta (zeige APP Proteine) aggregates by stimulating phagocytosis.
SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration
Results suggest that engagement of SIRPbeta promotes phagocytosis in macrophages by inducing the tyrosine phosphorylation of DAP12 (zeige TYROBP Proteine), Syk (zeige SYK Proteine), and SLP-76 (zeige LCP2 Proteine) and the subsequent activation of a MEK (zeige MDK Proteine)-MAPK (zeige MAPK1 Proteine)-myosin light chain kinase (zeige MYLK Proteine) cascade.
Sirp beta genes encode cell surface molecules containing extracellular Ig domains and short intracytoplasmic domains that have a charged amino acid in the transmembrane region which potentially interacts with ITAM-bearing molecules to mediate signaling.
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
signal-regulatory protein beta 1
, signal-regulatory protein gamma
, signal-regulatory protein beta-1 isoform 3-like
, CD172 antigen-like family member B
, signal-regulatory protein beta-1
, SIRP beta 1 cell surface protein
, SIRP-beta B