Sialidase 3 (Membrane Sialidase) Proteine (Neu3)

Mouse (Murine) Sialidase 3 (Membrane Sialidase) (Neu3) Interaktionspartner

1. the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets and concluded that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3 (zeige FOXP3 Proteine).

2. radiographs revealed abnormalities in the skeletal bones of the Hexa (zeige HEXA Proteine)(-/-)Neu3(-/-) mice

3. These results suggest that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx, and that the presence of NEU3 on the exosomal surface could represent a useful marker for the detection of these nanovesicles

4. findings implicate NEU3 as a potential biomarker of insulin (zeige INS Proteine) sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.

5. NEU3 regulates the detergent resistant membrane ganglioside content.

6. NEU3 up-regulation stimulates the EGF receptor (zeige EGFR Proteine) signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha (zeige HIF1A Proteine)), resulting in a final increase of cell survival and proliferation.

7. NEU3 plays an important role in inflammation-dependent tumor development

8. Data indicate that sialidases Neu1 (zeige NEURL Proteine) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

9. The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step.

10. NEU3 participates in the control of insulin (zeige INS Proteine) signaling via modulation of gangliosides and interaction with Grb2 (zeige GRB2 Proteine)

Human Sialidase 3 (Membrane Sialidase) (Neu3) Interaktionspartner

1. This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas

2. effect of overexpression on EGFR (zeige EGFR Proteine) downstream pathway activation and TKI targeted therapies sensitivity in non-small cell lung cancer cell lines

3. The most potent compound tested targeted the human Neu4 (zeige NEU4 Proteine) isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions

4. NEU3 possesses the ability to interact with specific proteins, many of which are different in each cell compartment, supporting NEU3 involvement in the cell stress response, protein folding, and intracellular trafficking.

5. findings identify NEU3 as a participant in head and neck squamous cell carcinoma progression

6. Besides the already reported indirect EGFR (zeige EGFR Proteine) activation through GM3 (zeige GRM6 Proteine), sialidase NEU3 could also play a role on EGFR (zeige EGFR Proteine) activation through its desialylation.

7. NEU3 promotes anchorage-independent growth and in vivo tumorigenicity.

8. In the plasma membrane, NEU3 has a role in endocytosis and protein binding at the cell surface.

9. Results indicate an essential contribution of NEU3 to tumorigenic potential through maintenance of stem-like characteristics of colon cancer cells by regulating Wnt (zeige WNT2 Proteine) signaling at the receptor level.

10. The results provide strong evidence that the serum sialidase is, in fact, NEU3, and this subtype may, therefore, be a potential utility for novel diagnosis of human cancers