Sialidase 3 (Membrane Sialidase) Proteine (Neu3)

Mouse (Murine) Sialidase 3 (Membrane Sialidase) (Neu3) Interaktionspartner

1. NEU1/3 activity mediates IL-6 production in lupus-prone mesangial cells possibly through an IgG-receptor complex signaling pathway.

2. Absence of Neu3 and Neu4 leads to defects in cell adhesion and differentiation of epithelial cells resulting in aberrant tubular offshoots that fail to remain connected with the main duct and male infertility. Hence Neu3 and Neu 4 play an essential role in the guidance of epithelial cells during early embryonic formation.

3. the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets and concluded that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3.

4. radiographs revealed abnormalities in the skeletal bones of the Hexa(-/-)Neu3(-/-) mice

5. These results suggest that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx, and that the presence of NEU3 on the exosomal surface could represent a useful marker for the detection of these nanovesicles

6. These results provide the first in vivo evidence that neuraminidases 3 and 4 have important roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin bodies.

7. findings implicate NEU3 as a potential biomarker of insulin sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.

8. NEU3 regulates the detergent resistant membrane ganglioside content.

9. NEU3 up-regulation stimulates the EGF receptor signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha), resulting in a final increase of cell survival and proliferation.

10. NEU3 plays an important role in inflammation-dependent tumor development

11. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

12. The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step.

13. It exists in membrane microdomains and regulates signal transductions. (review)

14. NEU3 participates in the control of insulin signaling via modulation of gangliosides and interaction with Grb2

15. MmNEU3 is able to hydrolyze ganglioside substrates in intact living cells at a neutral pH, mainly through cell-to-cell interactions

16. NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility.

17. Reduction of 70% of the plasma membrane-associated sialidase Neu3 activity caused neurite elongation in Neuro2a murine neuroblastoma cells.

18. findings suggest that the Neu3 gene represents a physiological modulator of VSMC responses that may contribute to plaque instability in atherosclerosis.

19. The decrease of GD1a in COS7 cell membrane upon MmNEU3 over-expression is likely to be instrumental to Newcastle Disease Virus reduced infection.

20. NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis

Human Sialidase 3 (Membrane Sialidase) (Neu3) Interaktionspartner

1. this finding strongly supports the idea that Neu3 may contain a cytosolic-exposed domain.

2. This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas

3. effect of overexpression on EGFR downstream pathway activation and TKI targeted therapies sensitivity in non-small cell lung cancer cell lines

4. The most potent compound tested targeted the human Neu4 isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions

5. NEU3 possesses the ability to interact with specific proteins, many of which are different in each cell compartment, supporting NEU3 involvement in the cell stress response, protein folding, and intracellular trafficking.

6. findings identify NEU3 as a participant in head and neck squamous cell carcinoma progression

7. Besides the already reported indirect EGFR activation through GM3, sialidase NEU3 could also play a role on EGFR activation through its desialylation.

8. NEU3 promotes anchorage-independent growth and in vivo tumorigenicity.

9. In the plasma membrane, NEU3 has a role in endocytosis and protein binding at the cell surface.

10. Results indicate an essential contribution of NEU3 to tumorigenic potential through maintenance of stem-like characteristics of colon cancer cells by regulating Wnt signaling at the receptor level.

11. The results provide strong evidence that the serum sialidase is, in fact, NEU3, and this subtype may, therefore, be a potential utility for novel diagnosis of human cancers

12. Studies indicate that ganglioside-specific sialidase NEU3 cleaves sialic acids preferentially from gangliosides.

13. Weak anchorage of NEU1 and NEU3 to the plasma membrane and their loss during erythrocyte life could be a tool to preserve the cellular sialic acid content to avoid early aging of erythrocyte and processes of cell aggregation in the capillaries.

14. NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in renal cell carcinomas malignancy.

15. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

16. Data show that NEU1 was immunolocalized to both the plasma membrane and the perinuclear region, and NEU3 was detected both in the cytosol and nucleus.

17. These data suggest that NEU3 regulates tumor progression through AR signaling, and thus be a potential tool for diagnosis and therapy of androgen-independent prostate cancer.

18. NEU3 is highly expressed to enhance malignant phenotypes including apoptosis inhibition in malignant melanomas.

19. observed that trisaccharides with incorporated azide groups in the Neu5Ac residue at either C9 or the N5-Ac position were substrates, and in the case of the N5-azidoacetyl derivative, the activity was superior to that of GM3

20. Truncations at the N- or C-terminus of more than 10 residues abolished enzyme activity.