Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) ELISA Kits

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Zusätzlich bieten wir Ihnen SIGLEC8 Antikörper (65) und SIGLEC8 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

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SIGLEC8 27181 Q9NYZ4
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Top SIGLEC8 ELISA Kits auf

Showing 7 out of 20 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 bis 18 Tage
Schwein 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
Kaninchen 37.5 pg/mL 62.5-4000 pg/mL   96 Tests 12 bis 14 Tage
Huhn 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
  96 Tests 12 bis 14 Tage
Human 0.058 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 8 bis 12 Tage
Schaf 0.469 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests 11 bis 18 Tage

Am meisten referenzierte SIGLEC8 ELISA Kits

  1. Human SIGLEC8 ELISA Kit für Sandwich ELISA - ABIN1117102 : Arakawa, Suzukawa, Ohshima, Tashimo, Asari, Matsui, Kobayashi, Shoji, Nagase, Ohta: Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab. in Allergology international : official journal of the Japanese Society of Allergology 2019 (PubMed)

Weitere ELISA Kits für SIGLEC8 Interaktionspartner

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaktionspartner

  1. These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases

  2. Targeting saporin to Siglec-8 consistently caused extensive cell death.

  3. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2.

  4. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  5. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  6. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  7. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  8. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping

  9. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  10. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis.

  11. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.

  12. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  13. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells

  14. The Siglec-8 gene may be a susceptibility locus for asthma.

  15. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis

  16. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  17. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage.

  18. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.

  19. First reported inhibitory effects of Siglec engagement on human mast cells.

  20. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils.

SIGLEC8 Antigen-Profil

Beschreibung des Gens

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Genbezeichner und Symbole assoziert mit SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8) Antikörper
  • sialic acid-binding Ig-like lectin 8 (LOC506364) Antikörper
  • SAF2 Antikörper
  • SIGLEC-8 Antikörper
  • SIGLEC8 Antikörper
  • SIGLEC8L Antikörper

Bezeichner auf Proteinebene für SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
Ausgewählte Anbieter für SIGLEC8 (SIGLEC8) ELISA Kits
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