Sialic Acid Binding Ig-Like Lectin 15 Proteine (SIGLEC15)

Binds sialylated glycoproteins..

alle Proteine anzeigen Gen GeneID UniProt
Ratte SIGLEC15 SIGLEC15 498888  
Human SIGLEC15 SIGLEC15 284266 Q6ZMC9
Maus SIGLEC15 SIGLEC15 620235  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
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Weitere Proteine zu Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15) Interaktionspartnern

Human Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15) Interaktionspartner

  1. Siglec-15 recognizes the tumoral sTn (zeige EEF1A2 Proteine) antigen and transduces a signal for enhanced TGF-beta (zeige TGFB1 Proteine) secretion in TAMs

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15) Interaktionspartner

  1. Siglec-15 does not mediate joint destruction in inflammatory arthritis

  2. The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.

  3. Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL (zeige TNFSF11 Proteine)) signaling in association with DAP12 (zeige TYROBP Proteine).

  4. DC-STAMP, Siglec-15, Tspan7 (zeige TSPAN7 Proteine) and Mst1r (zeige MST1R Proteine) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.

  5. results reveal the importance of Siglec-15 in the regulation of osteoclast formation and/or function in vivo, providing new insights into osteoclast biology

  6. the Siglec-15-DAP12 (zeige TYROBP Proteine)-Syk (zeige SYK Proteine)-signaling cascade plays a critical role in functional osteoclast formation.

  7. These results suggest that Siglec-15 plays an important role in osteoclast differentiation.

SIGLEC15 Protein Überblick

Protein Überblick

Binds sialylated glycoproteins.

Genbezeichner und Symbole assoziert mit SIGLEC15

  • sialic acid binding Ig-like lectin 15 (Siglec15)
  • sialic acid binding Ig like lectin 15 (SIGLEC15)
  • Cd33l3 Protein
  • EG620235 Protein
  • HsT1361 Protein
  • RGD1565948 Protein
  • SIGLEC-15 Protein
  • SIGLEC-I Protein

Bezeichner auf Proteinebene für SIGLEC15

sialic acid-binding Ig-like lectin 15 , CD33 antigen-like 3 , CD33 molecule-like 3

GENE ID SPEZIES
498888 Rattus norvegicus
284266 Homo sapiens
620235 Mus musculus
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