Sialic Acid Binding Ig-Like Lectin 15 Proteine (SIGLEC15)

Binds sialylated glycoproteins..

alle Proteine anzeigen	Gen	GeneID	UniProt
Ratte SIGLEC15	SIGLEC15	498888
Human SIGLEC15	SIGLEC15	284266	Q6ZMC9
Maus SIGLEC15	SIGLEC15	620235

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Katalog Nr.	Origin	Quelle	Konjugat	Bilder	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN3077113	Insektenzellen	Human	His tag		1 mg	Anmelden zum Anzeigen	50 Days	$5,960.83	Details

Siglec-15 recognizes the tumoral sTn (zeige EEF1A2 Proteine) antigen and transduces a signal for enhanced TGF-beta (zeige TGFB1 Proteine) secretion in TAMs

Siglec-15 does not mediate joint destruction in inflammatory arthritis
The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.
Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL (zeige TNFSF11 Proteine)) signaling in association with DAP12 (zeige TYROBP Proteine).
DC-STAMP, Siglec-15, Tspan7 (zeige TSPAN7 Proteine) and Mst1r (zeige MST1R Proteine) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
results reveal the importance of Siglec-15 in the regulation of osteoclast formation and/or function in vivo, providing new insights into osteoclast biology
the Siglec-15-DAP12 (zeige TYROBP Proteine)-Syk (zeige SYK Proteine)-signaling cascade plays a critical role in functional osteoclast formation.
These results suggest that Siglec-15 plays an important role in osteoclast differentiation.

Binds sialylated glycoproteins.

sialic acid-binding Ig-like lectin 15 , CD33 antigen-like 3 , CD33 molecule-like 3

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