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Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen SIGLEC12 Antikörper (58) und SIGLEC12 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.
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cardiovascular outcomes may differ based on SIGLEC12 genotype, and antihypertensive treatment strategy.
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
The Siglec-E-deficient dendritic cells were defective for TRIF (zeige RNF138 Proteine)-mediated IFN-beta (zeige IFNB1 Proteine) production in response to E. coli infection.
This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (zeige SIGLEC1 Proteine).
new data relating to the structure and function of Siglec-E, the major CD33 (zeige CD33 Proteine)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.
indicate that Siglec-9 (zeige SIGLEC9 Proteine) affects several different signaling pathways in IL-4 (zeige IL4 Proteine)-stimulated macrophages, which resulted in enhanced induction of Arg1 (zeige ARG1 Proteine) in Siglec-9 (zeige SIGLEC9 Proteine)-expressing RAW264 cells
Competitive ELISA assays confirmed the involvement of sulfated (zeige SULF1 Proteine) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment
Data indicate a role for neuraminidase 1 (Neu1 (zeige NEU1 Proteine)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) interaction and endotoxemia.
Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (zeige CD33 Proteine)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.
siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (zeige NOX1 Proteine) activation and ROS (zeige ROS1 Proteine) production
These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (zeige MUC1 Proteine)-expressing tumor in the transgenic mice.
Siglec-9 (zeige SIGLEC9 Proteine) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (zeige MUC1 Proteine) and that this signaling may be another MUC1 (zeige MUC1 Proteine)-mediated pathway and function in parallel with a growth factor-dependent pathway.
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
, sialic acid binding immunoglobulin-like lectin-like protein 1
, sialic acid-binding Ig-like lectin 12
, sialic acid-binding Ig-like lectin-like 1
, sialic acid-binding lectin Siglec-L1
, sialic acid binding Ig-like lectin 12
, myeloid inhibitory siglec
, sialic acid binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin E
, sialic acid-binding immunoglobulin-like lectin E