Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) Proteine (SIGLEC12)

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen SIGLEC12 Antikörper (58) und SIGLEC12 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIGLEC12 89858 Q96PQ1
SIGLEC12 83382 Q91Y57
SIGLEC12 450120 Q95LH0
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Top SIGLEC12 Proteine auf antikoerper-online.de

Showing 7 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$778.00
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Escherichia coli (E. coli) Maus His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$560.00
Details
Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,303.67
Details

SIGLEC12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,
Chimpanzee

Weitere Proteine zu Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) Interaktionspartnern

Human Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) Interaktionspartner

  1. cardiovascular outcomes may differ based on SIGLEC12 genotype, and antihypertensive treatment strategy.

  2. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 12 (Gene/pseudogene) (SIGLEC12) Interaktionspartner

  1. The Siglec-E-deficient dendritic cells were defective for TRIF (zeige RNF138 Proteine)-mediated IFN-beta (zeige IFNB1 Proteine) production in response to E. coli infection.

  2. This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (zeige SIGLEC1 Proteine).

  3. new data relating to the structure and function of Siglec-E, the major CD33 (zeige CD33 Proteine)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.

  4. indicate that Siglec-9 (zeige SIGLEC9 Proteine) affects several different signaling pathways in IL-4 (zeige IL4 Proteine)-stimulated macrophages, which resulted in enhanced induction of Arg1 (zeige ARG1 Proteine) in Siglec-9 (zeige SIGLEC9 Proteine)-expressing RAW264 cells

  5. Competitive ELISA assays confirmed the involvement of sulfated (zeige SULF1 Proteine) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  6. Data indicate a role for neuraminidase 1 (Neu1 (zeige NEU1 Proteine)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) interaction and endotoxemia.

  7. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (zeige CD33 Proteine)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  8. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (zeige NOX1 Proteine) activation and ROS (zeige ROS1 Proteine) production

  9. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (zeige MUC1 Proteine)-expressing tumor in the transgenic mice.

  10. Siglec-9 (zeige SIGLEC9 Proteine) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (zeige MUC1 Proteine) and that this signaling may be another MUC1 (zeige MUC1 Proteine)-mediated pathway and function in parallel with a growth factor-dependent pathway.

SIGLEC12 Protein Überblick

Protein Überblick

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit SIGLEC12

  • sialic acid-binding Ig-like lectin 13 (LOC484344)
  • sialic acid binding Ig like lectin 12 (SIGLEC12)
  • sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12)
  • sialic acid-binding Ig-like lectin 13 (LOC618463)
  • sialic acid binding Ig-like lectin E (Siglece)
  • Cd170 Protein
  • mSiglec-E Protein
  • S2V Protein
  • Siglec-XII Protein
  • Siglec5 Protein
  • Siglec9 Protein
  • Siglec12 Protein
  • Siglecl1 Protein
  • SLG Protein

Bezeichner auf Proteinebene für SIGLEC12

SIGLEC-like 1 , sialic acid binding immunoglobulin-like lectin-like protein 1 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding lectin Siglec-L1 , siglec-12 , siglec-L1 , sialic acid binding Ig-like lectin 12 , MIS , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding immunoglobulin-like lectin E , siglec-5 , siglec-E

GENE ID SPEZIES
484344 Canis lupus familiaris
450120 Pan troglodytes
89858 Homo sapiens
618463 Bos taurus
83382 Mus musculus
Ausgewählte Anbieter für SIGLEC12 Proteine (SIGLEC12)
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