Siah E3 Ubiquitin Protein Ligase 2 Proteine (SIAH2)

SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Zusätzlich bieten wir Ihnen SIAH2 Antikörper (66) und SIAH2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIAH2 6478 O43255
SIAH2 20439 Q06986
SIAH2 140593 Q8R4T2
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Top SIAH2 Proteine auf

Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

SIAH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartnern

Human Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. DHX15 (zeige DHX15 Proteine) regulates androgen receptor (AR (zeige AR Proteine)) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression.

  2. the Siah2-PHD3 (zeige EGLN3 Proteine)- HIF-1alpha (zeige HIF1A Proteine)-VEGF (zeige VEGFA Proteine) axis is an important hypoxic signaling pathway in a leukemic microenvironment.

  3. Based on the proposition that NS5 (zeige RAF1 Proteine) utilizes SIAH2-mediated proteasomal degradation of STAT2 (zeige STAT2 Proteine), an in-silico study was carried out to characterize the protein-protein interactions between NS5 (zeige RAF1 Proteine), SIAH2 and STAT2 (zeige STAT2 Proteine) proteins.

  4. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  5. Study identified SIAH1 (zeige SIAH1 Proteine)/2 (SIAH (zeige SIAH1 Proteine)) as the E3 ligase mediating Wnt (zeige WNT2 Proteine)-induced Axin (zeige AXIN1 Proteine) degradation. SIAH (zeige SIAH1 Proteine) proteins promote the ubiquitination and proteasomal degradation of Axin (zeige AXIN1 Proteine) through interacting with a VxP motif in the GSK3-binding domain of Axin (zeige AXIN1 Proteine), and this function of SIAH (zeige SIAH1 Proteine) is counteracted by GSK3 binding to Axin (zeige AXIN1 Proteine).

  6. SIAH2 regulates CHK2 (zeige CHEK2 Proteine) basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  7. study revealed an interesting mutual regulation between Plk3 (zeige PLK3 Proteine) and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.

  8. ETS2 (zeige ETS2 Proteine) and Twist1 (zeige TWIST1 Proteine) promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2

  9. Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK (zeige EPHB2 Proteine) and PI3K (zeige PIK3CA Proteine) pathway.

  10. Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.

Xenopus laevis Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus

Mouse (Murine) Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. The results suggest that SIAH2 plays a pivotal role to promote Th17 cell differentiation through maintaining the stability of HIF-1alpha (zeige HIF1A Proteine) protein.

  2. High Siah2 expression is associated with increased adipogenesis.

  3. Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (zeige HIF1A Proteine) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.

  4. Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.

  5. A catalysis-independent role for AKR1C3 (zeige AKR1C3 Proteine) on AR activity via Siah2 has been identified.

  6. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.

  7. Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions

  8. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (zeige TP53BP2 Proteine) stability.

  9. Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival

  10. modulation of PPARgamma (zeige PPARG Proteine) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (zeige PPARG Proteine) activation in adipocytes

SIAH2 Protein Überblick

Protein Überblick

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Genbezeichner und Symbole assoziert mit SIAH2

  • siah E3 ubiquitin protein ligase 2 (SIAH2)
  • siah E3 ubiquitin protein ligase 2 L homeolog (siah2.L)
  • seven in absentia 2 (Siah2)
  • siah E3 ubiquitin protein ligase 2 (Siah2)
  • AA415433 Protein
  • hSiah2 Protein
  • siah2-A Protein
  • Sinh2 Protein
  • Xsiah-2 Protein
  • xsiah2 Protein

Bezeichner auf Proteinebene für SIAH2

E3 ubiquitin-protein ligase SIAH2 , seven in absentia homolog 2 , siah-2 , seven in absentia-like protein , E3 ubiquitin-protein ligase siah2 , mSiah2 , seven in absentia 2

6478 Homo sapiens
429164 Gallus gallus
785659 Bos taurus
100034000 Equus caballus
100622531 Sus scrofa
373622 Xenopus laevis
20439 Mus musculus
140593 Rattus norvegicus
100683719 Canis lupus familiaris
100718979 Cavia porcellus
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