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SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family.
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The results suggest that SIAH2 plays a pivotal role to promote Th17 cell differentiation through maintaining the stability of HIF-1alpha (zeige HIF1A Proteine) protein.
High Siah2 expression is associated with increased adipogenesis.
Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (zeige HIF1A Proteine) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.
Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.
A catalysis-independent role for AKR1C3 (zeige AKR1C3 Proteine) on AR activity via Siah2 has been identified.
Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.
Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions
our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (zeige TP53BP2 Proteine) stability.
Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival
modulation of PPARgamma (zeige PPARG Proteine) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (zeige PPARG Proteine) activation in adipocytes
The E3 ubiquitin ligase (zeige MUL1 Proteine) activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.
Based on the proposition that NS5 (zeige RAF1 Proteine) utilizes SIAH2-mediated proteasomal degradation of STAT2 (zeige STAT2 Proteine), an in-silico study was carried out to characterize the protein-protein interactions between NS5 (zeige RAF1 Proteine), SIAH2 and STAT2 (zeige STAT2 Proteine) proteins.
The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.
Study identified SIAH1 (zeige SIAH1 Proteine)/2 (SIAH (zeige SIAH1 Proteine)) as the E3 ligase mediating Wnt (zeige WNT2 Proteine)-induced Axin (zeige AXIN1 Proteine) degradation. SIAH (zeige SIAH1 Proteine) proteins promote the ubiquitination and proteasomal degradation of Axin (zeige AXIN1 Proteine) through interacting with a VxP motif in the GSK3-binding domain of Axin (zeige AXIN1 Proteine), and this function of SIAH (zeige SIAH1 Proteine) is counteracted by GSK3 binding to Axin (zeige AXIN1 Proteine).
SIAH2 regulates CHK2 (zeige CHEK2 Proteine) basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.
study revealed an interesting mutual regulation between Plk3 (zeige PLK3 Proteine) and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.
ETS2 (zeige ETS2 Proteine) and Twist1 (zeige TWIST1 Proteine) promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2
Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK (zeige EPHB2 Proteine) and PI3K (zeige PIK3CA Proteine) pathway.
Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.
SIAH2 is associated with a tumor promoting role in breast cancer.
Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma
Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.
seven in absentia homolog 2
, seven in absentia-like protein
, E3 ubiquitin-protein ligase SIAH2
, E3 ubiquitin-protein ligase Siah2
, seven in absentia 2-like
, seven in absentia homolog 2-like
, ubiquitin ligase siah2
, seven in absentia 2
, E3 ubiquitin-protein ligase siah2