Siah E3 Ubiquitin Protein Ligase 2 Proteine (SIAH2)

SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Zusätzlich bieten wir Ihnen SIAH2 Antikörper (64) und SIAH2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIAH2 6478 O43255
SIAH2 20439 Q06986
SIAH2 140593 Q8R4T2
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Top SIAH2 Proteine auf

Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

SIAH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartnern

Human Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression.

  2. the Siah2-PHD3- HIF-1alpha-VEGF axis is an important hypoxic signaling pathway in a leukemic microenvironment.

  3. Based on the proposition that NS5 utilizes SIAH2-mediated proteasomal degradation of STAT2, an in-silico study was carried out to characterize the protein-protein interactions between NS5, SIAH2 and STAT2 proteins.

  4. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  5. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with a VxP motif in the GSK3-binding domain of Axin, and this function of SIAH is counteracted by GSK3 binding to Axin.

  6. SIAH2 regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  7. study revealed an interesting mutual regulation between Plk3 and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.

  8. ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2

  9. Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK and PI3K pathway.

  10. Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.

  11. SIAH2 is associated with a tumor promoting role in breast cancer.

  12. Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma

  13. Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia

  14. The expression of SIAH2 is increased in human lung cancer.

  15. the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of the Hippo pathway, in response to hypoxia.

  16. The down-regulation of SIAH2 conferred sensitivity to anti-cancer drugs. The results of the study indicated that the miR-335/SIAH2/HDAC3 axis regulates the response to anti-cancer drugs.

  17. Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor RevErbalpha (Nr1d1) and lengthens period length.

  18. Data indicate that ubiquitin ligase Siah as a regulator of to Mesenchymal Transition (EMT) by controlling the abundance of the key transcription factor Zeb1, while Siah itself is subject to regulation by EMT-inducing factors.

  19. A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified.

  20. molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity

Xenopus laevis Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus

Mouse (Murine) Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Interaktionspartner

  1. The results suggest that SIAH2 plays a pivotal role to promote Th17 cell differentiation through maintaining the stability of HIF-1alpha protein.

  2. High Siah2 expression is associated with increased adipogenesis.

  3. Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.

  4. Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.

  5. A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified.

  6. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.

  7. Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions

  8. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  9. Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival

  10. modulation of PPARgamma protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma activation in adipocytes

  11. Siah2 is a key regulator of hypoxia-induced mitochondrial fission and plays role in ischemic injury

  12. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

  13. Data characterized menadione as a specific inhibitor of Siah2 ligase activity, and show that growth of xenograft melanoma tumors was inhibited following the administration of MEN or its derivative.

  14. role as regulator of TRAF2 stability

  15. Results from loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis.

  16. Siah2 mutant bone marrow produces more osteoclasts in vitro than wild-type bone marrow.

  17. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

  18. role of Siah2 in tumorigenesis and metastasis by HIF-dependent and -independent mechanisms involving Ras signaling

SIAH2 Protein Überblick

Protein Überblick

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Genbezeichner und Symbole assoziert mit SIAH2

  • siah E3 ubiquitin protein ligase 2 (SIAH2)
  • siah E3 ubiquitin protein ligase 2 L homeolog (siah2.L)
  • seven in absentia 2 (Siah2)
  • siah E3 ubiquitin protein ligase 2 (Siah2)
  • AA415433 Protein
  • hSiah2 Protein
  • siah2-A Protein
  • Sinh2 Protein
  • Xsiah-2 Protein
  • xsiah2 Protein

Bezeichner auf Proteinebene für SIAH2

E3 ubiquitin-protein ligase SIAH2 , seven in absentia homolog 2 , siah-2 , seven in absentia-like protein , E3 ubiquitin-protein ligase siah2 , mSiah2 , seven in absentia 2

6478 Homo sapiens
429164 Gallus gallus
785659 Bos taurus
100034000 Equus caballus
100622531 Sus scrofa
373622 Xenopus laevis
20439 Mus musculus
140593 Rattus norvegicus
100683719 Canis lupus familiaris
100718979 Cavia porcellus
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