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Filament-forming cytoskeletal GTPase. Zusätzlich bieten wir Ihnen Septin 2 Antikörper (110) und Septin 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Study discloses both SEPT2 and SEPT7 (zeige SEPT7 Proteine) are essential for breast cancer cell migration and invasion by controlling MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) MAPKs activation.
Depletion of septin 2 reduces Drp1 recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission.
septins protect ErbB2 (zeige ERBB2 Proteine) from ubiquitylation, endocytosis and lysosomal degradation. Septin (zeige SEPT6 Proteine) oligomerization regulates persistent expression of ErbB2/HER2 (zeige ERBB2 Proteine) in gastric cancer cells.
The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR (zeige MLXIP Proteine)-140-5p.
From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2
These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN (zeige STMN1 Proteine)-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 (zeige CD99 Proteine) upregulation in Hodgkin lymphoma.
Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 and SEPT3 (zeige SEPT3 Proteine).
Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion.
Suggest PPAR-gamma (zeige PPARG Proteine) activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth.
SEPT2 forms a 1:1:1 complex with SEPT7 (zeige SEPT7 Proteine) and SEPT9 (zeige SEPT9 Proteine).
Results indicate a stimulatory role of septin-2 and the dynamic reorganization of septin (zeige SEPT6 Proteine) oligomers in exocytosis.
findings show SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium
Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin (zeige ADD2 Proteine), septin 2, and sh3p8 (zeige SH3GL1 Proteine) as putative paranodal proteins.
Significant level of SEPT2 expression was found in heart in a developmentally regulated fashion.
p85 (zeige ECM1 Proteine) is thus involved in the spatial control of cytosolic division through regulation of Cdc42 (zeige CDC42 Proteine) and septin 2, in a PI3K-activity independent manner.
study identified control of septin (zeige SEPT6 Proteine) localization by the planar cell polarity (PCP (zeige PRCP Proteine)) protein Fritz (zeige WDPCP Proteine) as a crucial control point for both collective cell movement and ciliogenesis in embryos
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
, septin 2
, neural precursor cell expressed developmentally down-regulated protein 5
, neural precursor cell expressed, developmentally down-regulated 5
, neural precursor cell expressed, developmentally down-regulated gene 5
, vascular endothelial cell specific protein 11
, septin A