Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E Proteine (SEMA3E)

Human Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E (SEMA3E) Interaktionspartner

1. Sema3E induced cell proliferation via acting through the MAPK/ERK (zeige MAPK1 Proteine) pathway.

2. Sema3E could be considered an essential regulatory mediator involved in modulation of neutrophil migration throughout the course of neutrophilic inflammation.

3. Results show high expression level of SEMA3E which correlated with lymph node involvement, metastatic progression and a significant association with poor prognosis in gastric cancer patients. Also, in vitro studies reveal that SEMA3E caused cell proliferation and anchorage-independent cell growth in the intestinal type of gastric cancer.

4. suggested that miR (zeige MLXIP Proteine)-4282 is a tumor suppressor in colorectal carcinoma cells and exerted its inhibitory effect on the tumor cells through targeting Sema3E by inhibiting Sema3E translation or enhancing Sema3E mRNA degradation

5. This study aims to investigate whether the Tribbles 3 (zeige TRIB3 Proteine) Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis.

6. This study suggests that NRP1 (zeige NELL1 Proteine) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (zeige CYP11A1 Proteine))of the tongue, whereas the expression of VEGFC (zeige VEGFC Proteine), VEGFR3 (zeige FLT4 Proteine), CCR7 (zeige CCR7 Proteine), and SEMA3E are nonindependent predictive factors

7. Authors suggest that silencing of Sema3E contributes to the pathogenesis of gastric cancer.

8. Findings suggest that Plexin-D1 (zeige PLXND1 Proteine)/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc (zeige CYP11A1 Proteine)) endothelium.

9. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F (zeige SEMA3F Proteine).

10. these results identify SEMA3E as an essential gene for GnRH (zeige GNRH1 Proteine) neuron development, uncover a neurotrophic function for SEMA3E in the developing brain

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E (SEMA3E) Interaktionspartner

1. that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis

2. The data indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways. More important, replenishment of Sema3E by intranasal administration of exogenous Sema3E protects mice from allergic asthma by reducing eosinophilic inflammation, serum IgE level, and T helper cell 2/T helper cell 17 cytokine response.

3. findings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events and suggest that targeting this molecule could be a novel approach to treat allergic asthma.

4. Our results demonstrate that sema3e/plexin D1 (zeige PLXND1 Proteine) modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues.

5. these results identify SEMA3E as an essential gene for GnRH (zeige GNRH1 Proteine) neuron development, uncover a neurotrophic function for SEMA3E in the developing brain

6. Sema3E is a natural negative regulator of the migration of PlexinD1-positive Cajal-Retzius (CR) cells originating in the cortical hem. Sema3E/PlexinD1 signaling controls the motogenic potential of CR cells in vitro and in vivo.

7. Our results indicate that Sema3e, secreted by damaged hepatocytes, affects sinusoidal regeneration in a paracrine manner during liver regeneration

8. Semaphorin 3d (zeige SEMA3D Proteine) requires neuropilin 1 (zeige NRP1 Proteine) or PI3K/Akt (zeige AKT1 Proteine), whereas semaphorin 3e requires plexin D1 (zeige PLXND1 Proteine) in directing endothelial motility.

9. Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools.

10. Sema3E acts as a chemoattractant for macrophages, with p53 (zeige TP53 Proteine)-induced upregulation of Sema3E expression provoking adipose tissue inflammation and systemic insulin (zeige INS Proteine) resistance in association with dietary obesity.