Secretory Leukocyte Peptidase Inhibitor Proteine (SLPI)

SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. Zusätzlich bieten wir Ihnen SLPI Antikörper (117) und SLPI Kits (45) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLPI 6590 P03973
SLPI 20568 P97430
Ratte SLPI SLPI 84386  
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Top SLPI Proteine auf

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) k.A. GST tag Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132), (full length) protein (GST tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
Baculovirus infected Insect Cells Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
Escherichia coli (E. coli) Human GST tag   50 μg Anmelden zum Anzeigen 11 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Maus His tag,S tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

SLPI Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine) ,

Weitere Proteine zu Secretory Leukocyte Peptidase Inhibitor (SLPI) Interaktionspartnern

Human Secretory Leukocyte Peptidase Inhibitor (SLPI) Interaktionspartner

  1. these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection

  2. we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (zeige GRN Proteine) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment

  3. Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.

  4. The results indicate that SERPINE2 (zeige SERPINE2 Proteine) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.

  5. Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.

  6. Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2 (zeige ANXA2 Proteine).

  7. SLPI is an independent predictor for both OS and DSS (zeige NR0B1 Proteine) and a relevant prognostic biomarker in OSCC.

  8. The elevations in cervical elafin (zeige PI3 Proteine) and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.

  9. These results demonstrate that SLPI down-regulates pIgR (zeige PIGR Proteine) expression through the NF-kappaB (zeige NFKB1 Proteine) signaling pathway by inhibiting degradation of IkappaBbeta (zeige NFKBIB Proteine) protein.

  10. Abnormal over-expression of SLPI in pancreatic cancer cells may be associated with the development of disease through its roles in promoting cancer cell survival and proliferation as well as anti-apoptosis.

Mouse (Murine) Secretory Leukocyte Peptidase Inhibitor (SLPI) Interaktionspartner

  1. MIF-2 (zeige HSPA5 Proteine)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (zeige ATF4 Proteine)-dependent mechanisms.

  2. Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (zeige TGFB1 Proteine) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.

  3. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (zeige NFE2L2 Proteine)-mediated control of SLPI and syndecan 4 (zeige SDC4 Proteine).

  4. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (zeige IFNG Proteine)/SLPI axis that affects lung function.

  5. Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.

  6. Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (zeige S100A8 Proteine), and lactotransferrin (zeige LTF Proteine), was reduced due to myeloid differentiation dactor 88 (MyD88 (zeige MYD88 Proteine)) deficiency.

  7. a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1

  8. These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.

  9. In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity

  10. The results underscore the importance of SLPI as a modulator of specific immunity that can also function at peripheral sites under pathogenic pressure.

SLPI Protein Überblick

Protein Überblick

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.

Genbezeichner und Symbole assoziert mit SLPI

  • secretory leukocyte peptidase inhibitor (SLPI)
  • antileukoproteinase (LOC512548)
  • secretory leukocyte peptidase inhibitor (Slpi)
  • ALK1 Protein
  • ALP Protein
  • BLPI Protein
  • ckpi Protein
  • HUSI Protein
  • HUSI-I Protein
  • MATN4 Protein
  • MPI Protein
  • SLPI Protein
  • WAP4 Protein
  • WFDC4 Protein

Bezeichner auf Proteinebene für SLPI

antileukoproteinase , matrilin 4 , secretory leukocyte peptidase inhibitor , HUSI-1 , WAP four-disulfide core domain protein 4 , mucus proteinase inhibitor , protease inhibitor WAP4 , secretory leukocyte protease inhibitor (antileukoproteinase) , seminal proteinase inhibitor , ALP , secretory leukocyte protease inhibitor

504598 Bos taurus
711156 Macaca mulatta
740668 Pan troglodytes
100137514 Papio anubis
100137521 Pongo abelii
512548 Bos taurus
6590 Homo sapiens
20568 Mus musculus
84386 Rattus norvegicus
100722975 Cavia porcellus
396886 Sus scrofa
641306 Ovis aries
100127207 Canis lupus familiaris
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