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mouse homolog plays a role in the transport and activation of proprotein convertase-2 (PC2); may regulate hormone secretion. Zusätzlich bieten wir Ihnen Secretogranin V (7B2 Protein) Proteine (17) und Secretogranin V (7B2 Protein) Kits (16) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 32 products:
Human Monoclonal SCG5 Primary Antibody für ELISA, WB - ABIN562854
Lee, Ryu, Joo, Choi, Lee, Kim, Kim, Yoon: ?-Melanocyte-stimulating hormone inhibits tumor necrosis factor ?-stimulated MUC5AC expression in human nasal epithelial cells. in American journal of respiratory cell and molecular biology 2011
Human Polyclonal SCG5 Primary Antibody für IHC, IHC (p) - ABIN4352447
Lindskog, Korsgren, Pontén, Eriksson, Johansson, Danielsson: Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. in Journal of proteomics 2012
Dynamic modulation of prohormone convertase 2 (PC2 (zeige PCSK2 Antikörper))-mediated precursor processing by 7B2 protein has a preferential effect on glucagon (zeige GCG Antikörper) synthesis
7B2-related peptides modulate regulated secretion of ACTH (zeige POMC Antikörper) in neuroendocrine cells.
7B2 nulls exhibit a multisystem disorder of vital organs, most notably the liver, in which massive steatosis and necrosis are observed. Metabolic derangements in glucose metabolism result in glycogen (zeige GYS1 Antikörper) and fat deposition in liver
7B2 has a role in endoproteolytic processing in mouse brain
data indicate that null prohormone convertase 2 (zeige PCSK2 Antikörper) and 7B2 protein are not phenotypically equivalent in pituitary proopiomelanocortin (POMC (zeige POMC Antikörper)) biosynthesis and granule content
Phenotypic differences between the 7B2 and PC2 (zeige CBX4 Antikörper) nulls and play a life-or-death role in the ACTH (zeige POMC Antikörper) hypersecretion syndrome present in both 129 nulls.
phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP (zeige HSPA5 Antikörper), which impairs its ability to bind substrate
Differential expression of 7B2 may contribute to the difference between B6 and C3H mice not only in glucagon (zeige GCG Antikörper) production and secretion but also in glucose tolerance.
a role for Scg5 in the modulation of body weight
7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 (zeige CBX4 Antikörper) forms from losing catalytic competence and then aggregating.
Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 (zeige GREM1 Antikörper) duplication.
FAM20C (zeige FAM20C Antikörper) plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing.
7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP
conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers
data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease
the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas.
SGNE1 was overexpressed in gastrointestinal peptide (zeige SPINK4 Antikörper)-independent ACTH (zeige POMC Antikörper)-independent macronodular adrenal hyperplasia. hyperplasia
SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development.
SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin (zeige INS Antikörper) resistance, especially in the background of severe and early onset obesity
mouse homolog plays a role in the transport and activation of proprotein convertase-2 (PC2)\; may regulate hormone secretion
neuroendocrine protein 7B2
, secretogranin V
, secretory granule endocrine protein I
, secretory granule neuroendocrine protein 1, 7B2 protein
, Secretory granule neuroendocrine, protein 1 (7B2 protein)
, secretory granule neuroendocrine protein 1
, pituitary polypeptide
, prohormone convertase chaperone
, secretory granule, neuroendocrine protein 1 (7B2 protein)
, neuronal endocrine protein