Sec23 Homolog B (S. Cerevisiae) Proteine (SEC23B)

The protein encoded by SEC23B is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. Zusätzlich bieten wir Ihnen Sec23 Homolog B (S. Cerevisiae) Antikörper (38) und Sec23 Homolog B (S. Cerevisiae) Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SEC23B 10483 Q15437
Ratte SEC23B SEC23B 362226  
SEC23B 27054 Q9D662
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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SEC23B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Sec23 Homolog B (S. Cerevisiae) (SEC23B) Interaktionspartnern

Human Sec23 Homolog B (S. Cerevisiae) (SEC23B) Interaktionspartner

  1. A Y462C mutation was found in 5 members of a consanguineous Indian family. In the homozygous patient, it resulted in congenital dyserythropoietic anemia type II.

  2. described the functional interaction between GATA1 and SEC23B genes in two patients with suspected congenital dyserythropoietic anemia type II

  3. these data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes.

  4. novel compound mutations of c.1727T>C and c.1831C>T of the SEC23B gene probably underlie the congenital dyserythropoietic anemia type II in the family

  5. Mutation in SEC23B gene is associated with congenital dyserythropoietic anemia.

  6. miR-130a is an epigenetically regulated miRNA involved in regulation of key molecular and phenotypic features of prostate carcinogenesis, acting as a tumour suppressor miRNA by targeting SEC23B and DEPDC1.

  7. SEC23B-Y462C congenital dyserythropoietic anemia type II is only seen in a distinct Indian community (Vaish) in whom a recessively inherited shared haplotype can be showed, consistent with a founder effect.

  8. Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer.

  9. Congenital dyserythropoietic anemia, type II with SEC23B exon 12 c.1385 A --> G mutation, and pseudo-Gaucher cells in two siblings has been described.

  10. ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.

  11. Both probands with congenital dyserythropoietic anemia IotaI in the second family were homozygotes of the SEC23B gene with mutation c.938G>A (R313H).

  12. Mutations in SEC23B lead to congenital dyserythropoietic anemia type II due to alterations in coat protein (COP)II complex trafficking machinery. [REVIEW]

  13. study identified four novel SEC23B mutations associated with ongenital dyserythropoietic anemia type II disease; also demonstrated that the genetic alteration results in a significant decrease of SEC23B transcript in erythroid precursors

  14. Data indicate that SEC23B founder mutations E109K and R14W account for about 54% of all mutations in CDA II patients in Italy; data suggest R14W occurred Southern Italy, E109K is more widespread within Europe.

  15. Correlation between SEC23B mutations and congenital dyserythropoietic anemia type II parameters shows that addition of one missense mutation and one nonsense mutation tends to produce a more severe presentation then association of two missense mutations.

  16. Most congenital dyserythropoietic anemia II patients in Israel are of Moroccan Jewish origin and carry a common SEC23B mutation, E109K, the first to be described as a founder mutation causing CDA II.

  17. found 19 novel variants in the homozygous or the compound heterozygous state in 28 CDA II patients from 21 unrelated families enrolled in the CDA II International Registry

  18. This study found SEC23B mutations in two patients previously classified as atypical congenital dyserythropoietic anemias presenting with hydrops foetalis.

  19. Hetero- or homozygous mutation of CDAN2 causes hypoglycosylation of band 3, accumulation and hypoglycosylation of polyglycosylceramides, and accumulation of lactotriaosylceramide.

  20. These results provide in vivo evidence for SEC23B selectivity in erythroid differentiation and show that SEC23A and SEC23B, although highly related paralogous secretory COPII components, are nonredundant in erythrocyte maturation.

Mouse (Murine) Sec23 Homolog B (S. Cerevisiae) (SEC23B) Interaktionspartner

  1. these data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes.

  2. SEC23B but not SEC23A is essential for murine pancreatic development.

  3. Acinar Sec23b deletion results in induction of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic cells and decreased pancreatic weight. These findings demonstrate that SEC23B is required for normal function of pancreatic acinar cells in adult mice.

  4. Results show that transplantation of SEC23B-deficient hematopoietic stem cells does not result in a hematopoietic stem cells phenotype.

  5. In SEC23B-deficient embryonic pancreas, defects occur in exocrine and endocrine tissues shortly after differentiation.

Sec23 Homolog B (S. Cerevisiae) (SEC23B) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.

Genbezeichner und Symbole assoziert mit SEC23B

  • Sec23 homolog B, COPII coat complex component L homeolog (sec23b.L)
  • Sec23 homolog B, coat complex II component (SEC23B)
  • Sec23 homolog B, COPII coat complex component (sec23b)
  • Sec23 homolog B, coat complex II component (Sec23b)
  • SEC23 homolog B, COPII coat complex component (Sec23b)
  • CDA-II Protein
  • CDAII Protein
  • CDAN2 Protein
  • HEMPAS Protein
  • SEC23A Protein
  • wu:fd19h01 Protein
  • wu:fl08h02 Protein
  • zgc:55595 Protein
  • zgc:86871 Protein

Bezeichner auf Proteinebene für SEC23B

SEC23-like protein B , SEC23-related protein B , protein transport protein Sec23B , transport protein SEC23B , SEC23B , fl08h02 , SEC23-related protein A , protein transport protein Sec23A

GENE ID SPEZIES
444834 Xenopus laevis
10483 Homo sapiens
327268 Danio rerio
416724 Gallus gallus
477142 Canis lupus familiaris
535071 Bos taurus
362226 Rattus norvegicus
27054 Mus musculus
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