SRY (Sex Determining Region Y)-Box 18 Proteine (SOX18)

Human SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. results suggest that SOX18 is overexpressed in Osteosaroma (OS) and plays an important role in proliferation, apoptosis, migration and invasion of OS cells, and may provide a novel and promising thera-peutic strategy for OS.

2. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction

3. A novel mutation in the SOX18 gene identified in a patient with hypotrichosis-lymphedema-telangiectasia syndrome.

4. Results showed that on the contrary of the mRNA level, the protein levels of SOX18 were higher in lung adenocarcinoma (AC) cases compared to levels noted in the non-malignant lung tissues (NMLTs). The disparity between the mRNA and protein levels of the SOX18 transcription factor was caused by miR-7a and miR-24-3p, although the mechanism through which lung cancer cells downregulate miRNA molecule levels is still unclear.

5. miR-7-5p targeted SOX18 to inhibit gp130/JAK2/STAT3 signaling pathway to exert its suppressing role in Pancreatic ductal adenocarcinoma

6. Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC cancer cells

7. SOX18 plays a significant role in promoting the growth of pancreatic ductal adenocarcinoma, and might serve as a promising target for PDAC therapy

8. Study reports SOX18 as novel risk gene for Neural tube defects (NTDs) but findings also suggest that SOX18 hypomethylation and increased expression must interplay with other environmental and (epi)genetic factors that are causative for NTDs.

9. SOX18 was overexpressed in prostate cancer.SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7.

10. the results of this study suggest that knockdown of SOX18 inhibits breast cancer cell growth and invasion, possibly by downregulating downstream oncogenic proteins, providing novel insights into the development of breast cancer therapy through targeting of SOX18.

11. miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination

12. The downregulation of SOX18 was found to significantly inhibit cell adhesion and invasion.

13. NKD2 inhibits SOX18 and MMP-2,7,9 expression and suppresses BGC823 cell xenograft growth. NKD2 methylation may serve as a poor prognostic and chemo-sensitive marker in human gastric cancer. NKD2 impedes gastric cancer metastasis by inhibiting SOX18.

14. GLI1 and GLI2, but not GLI3 are involved in the regulation of SOX18 gene expression in cervical carcinoma cell lines.

15. we demonstrated that upregulation of SOX18 was associated with a poor outcome in hepatocellular carcinoma patients

16. The genetic finding of a pathogenic SOX18 mutation enabled the diagnosis of the rare hypotrichosis-lymphedema-telangiectasia syndrome in our patient.

17. A new, autosomal dominant condition combining hypotrichosis-lymphedema-telangiectasia syndrome with renal defects is associated with a novel truncating mutation in the SOX18 gene.

18. SOX18 may be involved in the progression of Non small cell lung cancer.

19. SOX18wt has potent trans-activation proper- ties, while SOX18DN displayed dominant-negative effect.

20. Data suggest that SOX18 transcription factor expression may serve as a marker for a poor prognosis in invasive ductal breast carcinoma.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype

Mouse (Murine) SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. Sox18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types.

2. combined deletion of Sox7, Sox17, and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity

3. Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in Zebrafish.

4. Disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes.

5. SOX18 induction is a key step in mediating tumor lymphangiogenesis and metastasis

6. Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton.

7. Results indicate that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development.

8. These result can explain previously controversial data on the functional consequences of Sox18 mutations in mice and humans.

9. Sox17/Sox18 double-null embryos showed more severe defects in formation of anterior dorsal aorta and head/cervical microvasculature, and in some cases, aberrant differentiation of endocardial cells and defective fusion of the endocardial tube

10. findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies

11. SOX18 plays role in the vascular dysfunction in hypotrichosis-lymphedema-telangiectasia syndrome.

12. SOX7 and SOX17 are not normally expressed during lymphatic development, excluding a conventional redundancy mechanism with SOX18. Instead, these genes are activated specifically in the absence of SOX18 function, and only in certain strains.

13. Sox18 mRNA decreases during pulmonary hypertension induced by pulmonary fibrosis in mice.