SRY (Sex Determining Region Y)-Box 18 Proteine (SOX18)

Human SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. A novel mutation in the SOX18 gene identified in a patient with hypotrichosis-lymphedema-telangiectasia syndrome.

2. Results showed that on the contrary of the mRNA level, the protein levels of SOX18 were higher in lung adenocarcinoma (AC) cases compared to levels noted in the non-malignant lung tissues (NMLTs). The disparity between the mRNA and protein levels of the SOX18 transcription factor was caused by miR (zeige MLXIP Proteine)-7a and miR (zeige MLXIP Proteine)-24-3p, although the mechanism through which lung cancer cells downregulate miRNA molecule levels is still unclear.

3. miR-7 (zeige LILRB1 Proteine)-5p targeted SOX18 to inhibit gp130 (zeige IL6ST Proteine)/JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway to exert its suppressing role in Pancreatic ductal adenocarcinoma

4. Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC (zeige CYP11A1 Proteine) cancer cells

5. SOX18 plays a significant role in promoting the growth of pancreatic ductal adenocarcinoma, and might serve as a promising target for PDAC therapy

6. Study reports SOX18 as novel risk gene for Neural tube defects (NTDs) but findings also suggest that SOX18 hypomethylation and increased expression must interplay with other environmental and (epi (zeige TFPI Proteine))genetic factors that are causative for NTDs.

7. SOX18 was overexpressed in prostate cancer.SOX18 promotes prostate cancer progression via the regulation of TCF1 (zeige HNF1A Proteine), c-Myc (zeige MYC Proteine), cyclin D1 (zeige CCND1 Proteine) and MMP-7 (zeige MMP7 Proteine).

8. the results of this study suggest that knockdown of SOX18 inhibits breast cancer cell growth and invasion, possibly by downregulating downstream oncogenic proteins, providing novel insights into the development of breast cancer therapy through targeting of SOX18.

9. miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination

10. The downregulation of SOX18 was found to significantly inhibit cell adhesion and invasion.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. Here we demonstrate that VEGF (zeige VEGFA Proteine)-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype

Mouse (Murine) SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaktionspartner

1. Sox18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types.

2. combined deletion of Sox7 (zeige SOX7 Proteine), Sox17 (zeige SOX17 Proteine), and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (zeige SOX17 Proteine) allele largely restores arterial identity

3. Sox18 genetically interacts with VegfC (zeige VEGFC Proteine) to regulate lymphangiogenesis in Zebrafish.

4. SOX18 induction is a key step in mediating tumor lymphangiogenesis and metastasis

5. Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton.

6. Results indicate that Sox17 (zeige SOX17 Proteine) and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development.

7. These result can explain previously controversial data on the functional consequences of Sox18 mutations in mice and humans.

8. Sox17 (zeige SOX17 Proteine)/Sox18 double-null embryos showed more severe defects in formation of anterior dorsal aorta and head/cervical microvasculature, and in some cases, aberrant differentiation of endocardial cells and defective fusion of the endocardial tube

9. findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies

10. SOX18 plays role in the vascular dysfunction in hypotrichosis-lymphedema-telangiectasia syndrome.