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SOX17 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Zusätzlich bieten wir Ihnen SOX17 Antikörper (104) und SOX17 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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This study showed that 1 of 4 SNPs located near the SOX17 gene, rs1072737, was statistically associated with intracranial aneurysm (IA) formation in a Korean population. The MAF (zeige MAF ELISA Kits) of this variant (minor allele, C) showed a highly ethnic difference between Korean and European populations. Two SNPs rs10958409 and rs9298506 showed statistically significant associations with increased IA risk in the current meta-analysis.
The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone
SOX17 acts as a tumor suppressor in cholangiocarcinoma and its genetic, molecular and/or pharmacological restoration may represent a new promising therapeutic strategy.
Our results suggest that decreasing SOX17 levels may promote EC development and progression, and that by downregulating MAML3 expression and Wnt (zeige WNT2 ELISA Kits) signaling, SOX17 acts as a tumor suppressor that may improve outcome in patients with EC.
SOX2 (zeige SOX2 ELISA Kits) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (zeige MBD2 ELISA Kits) UTX to the SOX2 (zeige SOX2 ELISA Kits) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC (zeige PGC ELISA Kits) specification, with its target PRDM1 (zeige PRDM1 ELISA Kits) suppressing mesendodermal genes
Dedifferentiation of fibroblasts to CD34 (zeige CD34 ELISA Kits)(+) progenitor cells gives rise to endothelial cells and erythroblasts in a SOX17-dependent manner.
Study extracted and analyzed the experimentally validated 3D models of SOX17-HMG (zeige SSRP1 ELISA Kits) domain and beta-catenin (zeige CTNNB1 ELISA Kits); the molecular level disturbance in the two essential human proteins upon M76A and G103R mutation of SOX17, which further hampers the cell signaling phenomena for the human cytological developments beginning from gastrulation and endoderm formation.
SOX17 promoter is highly methylated in primary tumors and in corresponding plasma samples both in operable and advanced non-small cell lung cancer.
The definitive endoderm and foregut endoderm differentiation capabilities of Wnt (zeige WNT2 ELISA Kits) pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 (zeige FOXA2 ELISA Kits) and those of the transcription activator GATA4 (zeige GATA4 ELISA Kits) and the alpha-fetoprotein (AFP (zeige AFP ELISA Kits)) gene, respectively.
Knockdown of OCT4 (zeige POU5F1 ELISA Kits) during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 promoter, suggesting that OCT4 (zeige POU5F1 ELISA Kits) acts to induce removal of the Polycomb2 complex.
Targeted knockdown of Sox17 and Chd (zeige CHRD ELISA Kits) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (zeige LEFTY2 ELISA Kits), and heart and pancreas placement in the embryo.
knockout of dusp4 (zeige DUSP4 ELISA Kits) revealed a specific loss of sox17, establishing a new class of endoderm specification defect
Results describe sox17 cis-regulatory elements, and examine the specific input predictions of the gene regulatory networks.
The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17(+/-) embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.
Sox17 disruption in epithelial and stromal compartments led to inhibition of endometrial adenogenesis and a loss of reproductive capacity. Epithelium-specific Sox17 disruption resulted in normal adenogenesis although reproductive capacity remained impaired. Non-epithelial, Sox17-positive cells are necessary for adenogenesis and endometrial glands require Sox17 to properly function.
SOX-17 transcription factor is indispensable in developmental angiogenesis and as a positive feedback regulator of VEGF (zeige VEGFA ELISA Kits) signaling.
findings indicate the role of Sry (zeige SRY ELISA Kits)-related HMG (zeige SSRP1 ELISA Kits) box gene-17 (Sox17) in uterine receptivity to embryo implantation.
combined deletion of Sox7 (zeige SOX7 ELISA Kits), Sox17, and Sox18 (zeige SOX18 ELISA Kits) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity
Sox17 inhibition of Runx1 (zeige RUNX1 ELISA Kits) and Gata2 (zeige GATA2 ELISA Kits) maintains endothelial fate in endothelial-to-haematopoietic transition
Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation.
These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting.
the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut (zeige GUSB ELISA Kits) endoderm morphogenesis and the assembly of the basement membrane that separates gut (zeige GUSB ELISA Kits) endoderm from mesoderm.
Hhex and Cer1 (zeige CER1 ELISA Kits) are indispensable components of the Sox17 pathway for cardiopoiesis.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.
SRY-related HMG-box transcription factor SOX17
, transcription factor SOX-17
, SRY-box 17
, SRY-box containing gene 17
, HMG box transcription factor Sox17-alpha
, sox17 alpha
, transcription factor Sox-17-alpha
, HMG transcription factor SOX17
, SRY (sex determining region Y)-box 17
, sox7/17 protein
, LOW QUALITY PROTEIN: transcription factor SOX-17