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SPEG encodes a protein with similarity to members of the myosin light chain kinase family.
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Human Polyclonal SPEG Primary Antibody für ELISA, WB - ABIN4281054
Hsieh, Yoshizumi, Endege, Kho, Jain, Kashiki, de los Santos, Lee, Perrella, Lee: APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. in The Journal of biological chemistry 1996
Human Polyclonal SPEG Primary Antibody für IHC, IHC (p) - ABIN4281053
Agrawal, Pierson, Joshi, Liu, Ravenscroft, Moghadaszadeh, Talabere, Viola, Swanson, Haliloğlu, Talim, Yau, Allcock, Laing, Perrella, Beggs: SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy. in American journal of human genetics 2014
SPEG is present in cardiac muscle, where it plays a critical role; therefore, individuals with SPEG mutations additionally present with dilated cardiomyopathy.
Genomic rearrangement on APEG1 in arteriosclerosis was studied.
the RGD motif might play a role not only in the adhesion of Aortic Preferentially Expressed Protein-1 and extracellular proteins but also in intracellular protein (zeige CKAP2 Antikörper)-protein interactions
Acute loss of SPEG in hearts causes junctophilin-2 (zeige JPH2 Antikörper) de-phosphorylation leading to heart failure.
Disruption of the striated (zeige NSDHL Antikörper) preferentially expressed gene (Speg) locus leads to cardiac dysfunction and a phenotype consistent with dilated cardiomyopathy.
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined.
aortic preferentially expressed gene 1
, novel serine/threonine protein kinase
, striated muscle preferentially expressed protein kinase
, aortic preferentially expressed protein 1
, nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury
, striated muscle-specific serine/threonine-protein kinase