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Acts as a transcriptional repressor. Zusätzlich bieten wir Ihnen SIN3 Transcription Regulator Homolog B (Yeast) Antikörper (54) und viele weitere Produktgruppen zu diesem Protein an.
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High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer.
Low SIN3B expression is associated with Prostate Cancer Progression.
these results suggest that stress-induced Sin3B activation is p53 (zeige TP53 Proteine)-dependent and is essential for p53 (zeige TP53 Proteine)-mediated repression of its selective target genes.
The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners.
A conserved Myc (zeige MYC Proteine) region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 (zeige HDAC1 Proteine) is recruited to Myc (zeige MYC Proteine)-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc (zeige MYC Proteine).
this study highlights an essential role for Sin3B in IFN-c induced COL1A2 (zeige COL1A2 Proteine) repression in smooth muscle cells.
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
the essential role of Sin3B as an important associate of p53 (zeige TP53 Proteine) in mediating the cellular responses to stress and in the transcriptional repression of genes
identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1 (zeige HDAC1 Proteine), Mrg15 (zeige MORF4L1 Proteine), and the PHD (zeige PDC Proteine) finger-containing Pf1
disruption of the function of a specific Sin3A (zeige SIN3A Proteine)/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells
this study shows that negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39 (zeige RBM39 Proteine)
these results identify Sin3B as a novel and critical regulator of hematopoietic stem cells functions.
adrenergic stimulation induced complex formation between Ifrd1 (zeige IFRD1 Proteine), Sp1 (zeige SP1 Proteine) and mSIN3B, which is a component of the SIN (zeige POLR3E Proteine) complex containing histone deacetylase (zeige HDAC1 Proteine), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (zeige IFRD1 Proteine) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 (zeige SP1 Proteine) and the mSIN3 complex.
Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 (zeige BMI1 Proteine) depletion.
interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
RNF220 was identified as a novel ubiquitin ligase for Sin3B.
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).
paired amphipathic helix protein Sin3b
, SIN3 homolog B, transcription regulator
, SIN3 homolog B, transcriptional regulator
, SIN3 transcription regulator homolog B
, histone deacetylase complex subunit Sin3b
, transcriptional corepressor Sin3b
, transcriptional regulator, SIN3B
, transcriptional regulator, SIN3 yeast homolog B