SATB Homeobox 2 Proteine (SATB2)

Human SATB Homeobox 2 (SATB2) Interaktionspartner

1. There was a negative correlation between the expression levels of SATB2 and miR-34a.

2. A shift in the function of SATB2 in cortex over lifetime.

3. SATB2 is a useful marker for determining the primary sites of metastatic Krukenberg tumors of the ovary.

4. miR-3666 was reported to be downregulated in CRC tissues and overexpression of miR-3666 impaired the proliferation, migration and invasion of CRC cells by targeting SATB2 in the present study.

5. Study provides evidence that the molecular mechanisms that underpin schizophrenia and cognitive function include disruption of biological processes influenced by SATB2 as the brain is being organized and wired during development.

6. the associations between the cleft palate (CPO) and single nucleotide polymorphisms (SNPs) of special AT-rich sequence-binding protein 2 (SATB2), were investigated.

7. The Autism spectrum disorder candidate genes SATB2, CHD8 and EHMT1 show enriched expression in neurons, especially inhibitory neurons

8. up-regulation of miR-31 may underlie endothelial dysfunction in diabetes by targeting Satb2

9. SATB2 as an additional diagnostic marker for the diagnosis of an ovarian manifestation of low-grade appendiceal mucinous neoplasm

10. HNF4-alpha and particularly SATB2 may be helpful in the differential diagnosis of pulmonary adenocarcinoma and metastases of colorectal adenocarcinomas

11. The study identified that decreased expression of SATB2 was correlated with tumor progression and poor prognosis in non-small cell lung cancer (NSCLC) patients. Furthermore, SATB2 suppressed lung cancer cell invasion and metastasis and regulated the expression of EMT-related proteins and histone methylation by G9a.

12. this study shows that SATB2 is a diagnostic marker of sinonasal intestinal-type adenocarcinoma

13. SATB2 could serve as a promising diagnostic biomarker of colorectal cancer metastases.

14. SATB2 can be used as a supplementary marker along with CDX2 to identify 'colon-rectum' as the primary site in material from patients presenting with metastasis.

15. We describe the phenotype and genotype of 12 individuals with 10 unique (de novo in 11 of 11 tested) pathogenic variants (1 splice site, 5 frameshift, 3 nonsense, and 2 missense) in SATB2 and review all cases reported in the published literature caused by point alterations thus far

16. features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability

17. The mRNA level of SATB2 was lower in tumor tissues than in samples of corresponding unchanged kidney. The results of the presented study suggest the tumor-suppressing function of SATB2.

18. MiR-875-5pdirectly binds to the 3'untranslated region of SATB.2

19. These results strongly suggest that SATB2 prevents induction of EMT by suppressing expression of EMT-inducing transcription factors in NSCLC cells.

20. We describe here the identification of a de novo SATB2 point mutation in twin boys with cleft soft palate, dental anomalies, and development delay and compare the clinical presentation of SATB2 point mutation patients reported to date.

Mouse (Murine) SATB Homeobox 2 (SATB2) Interaktionspartner

1. Together, these findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory.

2. Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network.

3. Data indicate two special AT-rich sequence-binding protein 2 (SATB2) sequence variants in two unrelated patients presenting with Rett-like phenotypes.

4. results suggest that expression of Sp7 during the early stage of Satb2-induced osteogenic differentiation of BMSCs is regulated by miR-27a.

5. Data show that Satb2 is required by both callosal projection neurons and subcerebral projection neurons for proper differentiation and axon pathfinding.

6. Satb2 and Fezf2 regulation promotes subcerebral projection neuron identity in the developing cerebral cortex

7. Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development.

8. Target genes of miR-27a ware significantly up-regulated in Satb2-overexpressing cells.

9. A comprehensive overview of Satb2 expression in the adult mouse brain.

10. The Satb2 proteins are dispensable for X chromosome inactivation in mice.

11. the CB(1) receptor contributes to the generation of deep-layer cortical neurons by coupling endocannabinoid signals from the neurogenic niche to the intrinsic proneurogenic Ctip2/Satb2 axis

12. Our results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons.

13. Genetic evidence obtained in the mouse confirmed the importance of SATB2 regulation by miR-34b/c

14. SATB2 may play a crucial role in protecting against oxidative stress-induced osteoblast apoptosis.

15. Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex.

16. The transcription factor Satb2 is expressed by cortical neurons extending axons through the corpus callosum and is a determinant of callosal versus subcortical projection.

17. in SATB2-overexpressed MC3T3-E1 cells,genes closely associated with osteoblast differentiation were identified.

18. SATB2 as the first p63 binding partner that differentially influences AEC and EEC p63 mutant proteins

19. Osx is an upstream regulator of Satb2 during bone formation.

20. SATB2 acts as a potent transcription factor to enhance osteoblastogenesis and promote bone regeneration.