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anti-SARS-Coronavirus Nonstructural Protein 8 Antikörper

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anti-SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) Antikörper Primary Antibody

SARS-CoV NSP8 Reaktivität: SARS Coronavirus (SARS-CoV) FM, IEM, IP, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed 2
Produktnummer ABIN233792
Zzgl. Versandkosten $45.00 und $24.00 Trockeneis
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Typ Primary
    • Primary
  • Target SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
    • SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
    • Histone 3 (H3)
    • Epidermal Growth Factor Receptor (EGFR)
    • Tumor Protein P53 (TP53)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • CD4
    • Tumor Necrosis Factor alpha (TNF alpha)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Estrogen Receptor 1 (ESR1)
    • Interferon gamma (IFNG)
    • Nuclear Factor-kB p65 (NFkBP65)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Albumin (ALB)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • Jun Proto-Oncogene (JUN)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • Integrin alpha M (ITGAM)
    • CD3 epsilon (CD3E)
    • Myc Proto-Oncogene protein (MYC)
    • Histone H4
    • CD44
    • Interleukin 6 (IL6)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • CD8
    • Interleukin 2 Receptor, alpha (IL2RA)
    • Vimentin (VIM)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • VEGF Receptor 2 (VEGFR2)
    • Interleukin 2 (IL2)
    • Tuberous Sclerosis 1 (TSC1)
    • Amyloid beta (A4) Precursor Protein (APP)
    • Insulin Receptor Substrate 1 (IRS1)
    • CD5
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • CD3
    • Glial Fibrillary Acidic Protein (GFAP)
    • CD34
    • Mucin 1 (MUC1)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Catenin, beta (CATNB)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1)
    • Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1)
  • Anwendung
    • Fluorescence Microscopy (FM)
    • Immunoelectron Microscopy (IEM)
    • Immunoprecipitation (IP)
    • Western Blotting (WB)
  • Reaktivität
    • SARS Coronavirus (SARS-CoV)
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Wirt
    • Kaninchen
  • Klonalität
    • Polyclonal
  • Format
    • Liquid

SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) Antigen-Profil

Protein Überblick

Replicase polyprotein 1ab: Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Host translation inhibitor nsp1: Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response. {ECO:0000269|PubMed:23035226}. Non-structural protein 2: May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses. {ECO:0000269|PubMed:19640993}. Papain-like proteinase: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling. {ECO:0000269|PubMed:17692280, ECO:0000269|PubMed:19369340}. Non-structural protein 4: Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. {ECO:0000269|PubMed:23943763}. Proteinase 3CL-PRO: Ccleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence Also able to bind an ADP-ribose-1''- phosphate (ADRP). {ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:16271890}. Non-structural protein 6: Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes. {ECO:0000269|PubMed:24991833}. Non-structural protein 7: Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. {ECO:0000269|PubMed:22039154}. Non-structural protein 8: Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. {ECO:0000269|PubMed:22039154}. Non-structural protein 9: May participate in viral replication by acting as a ssRNA-binding protein. {ECO:0000269|PubMed:19153232}. Non-structural protein 10: Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation. {ECO:0000269|PubMed:22635272}. RNA-directed RNA polymerase: Responsible for replication and transcription of the viral RNA genome. {ECO:0000269|PubMed:22791111}. Helicase: Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium. {ECO:0000269|PubMed:12917423, ECO:0000269|PubMed:22615777}. Guanine-N7 methyltransferase: Enzyme possessing two ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. {ECO:0000269|PubMed:16549795, ECO:0000269|PubMed:20421945, ECO:0000269|PubMed:22635272}. Uridylate-specific endoribonuclease: Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. 2'-O-methyltransferase: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. {ECO:0000269|PubMed:18417574, ECO:0000269|PubMed:20421945, ECO:0000305}.

Genbezeichner und Symbole assoziert mit SARS-CoV NSP8

  • orf1ab polyprotein (pp1ab) (orf1ab) Antikörper
  • pp1a Antikörper
  • pp1ab Antikörper

Bezeichner auf Proteinebene für SARS-CoV NSP8

ORF1a polyprotein , ORF1ab polyprotein , orf1a polyprotein (pp1a)

1489680 SARS coronavirus

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