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The protein encoded by S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Zusätzlich bieten wir Ihnen S100A7 Antikörper (166) und S100A7 Kits (43) und viele weitere Produktgruppen zu diesem Protein an.
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Human S100A7 Protein expressed in Wheat germ - ABIN1319069
Shubbar, Vegfors, Carlström, Petersson, Enerbäck: Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation. in Breast cancer research and treatment 2012
Show all 3 Pubmed References
In this paper, we reviewed the emerging roles of S100A7 in the pathogenesis of psoriasis. In particular, we focus on the psoriatic cytokine network where S100A7 is involved. Finally, we discuss the possible use of S100A7 as therapeutic target in psoriasis.
S100A7 affects cell motility and invasion by regulating the RAB2A (zeige RAB2A Proteine)-associated MAPK (zeige MAPK1 Proteine) signaling cascades.
The promigratory function of S100A7 on tumor cells was confirmed in A431 cells where neutralizing monoclonal antibodies were able to block this effect.
a set of IL-17A (zeige IL17A Proteine)-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A (zeige DEFB4 Proteine), S100A7, IL19 (zeige IL19 Proteine) and CSF3 (zeige CSF3 Proteine), based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A (zeige IL17A Proteine).
Psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.
only S100A7ox exhibits antibacterial activity against select bacterial species. Metal substitution experiments suggest that the disulfide bonds in S100A7 may enhance metal sequestration by the His3Asp sites and thereby confer growth inhibitory properties to S100A7ox.
A significant increase of salivary psoriasin was observed in Systemic sclerosis patients when compared with other healthy and pathological controls.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (zeige AGER Proteine)-p38 MAPK (zeige MAPK14 Proteine) and calpain-1 (zeige CAPN1 Proteine) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
higher expression of Psoriasin was associated with local invasion in pancreatic cancers. Psoriasin expression is associated with pancreatic cancer cell growth, migration, cell-matrix adhesion, and invasion via regulation of MMPs
S100A7 induction by the Hippo-YAP (zeige YAP1 Proteine) pathway in cervical and glossopharyngeal squamous cell carcinoma has been described.
Psoriasin appears to be a part of the local host defence mechanisms in the udder and seems to be inducible by infection with E. coli.
Although present in boar seminal vesicles and seminal plasma, S100A7 was not detected in female porcine organs.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
S100 calcium binding protein A7
, S100 calcium-binding protein A7
, S100 calcium-binding protein A7 (psoriasin 1)
, protein S100-A7
, psoriasin 1
, calcium-binding protein in amniotic fluid 2
, dander minor allergen BDA11
, dermal allergen BDA11