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The protein encoded by S100A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.
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Furthermore, we identify flotillin-1 (FLOT1 (zeige FLOT1 Proteine)) and histone H1 (zeige H1F0 Proteine) as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1 (zeige LASP1 Proteine)-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.
In patients with rheumatoid arthritis, S100A11 is up-regulated and is associated with inflammation and disease activity.
S100A11 overexpression correlates with an aggressive malignant phenotype and may constitute a novel prognostic factor for HGSC
S100A11 is involved in homologous recombination by regulating the appearance of RAD51 (zeige RAD51 Proteine) in double strand break repair sites.
we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma.
higher S100A11 expression was associated with statistically significant decrease in disease-free survival in clear cell renal cell carcinoma (zeige MOK Proteine)
the up-regulation of S100A11 plays a role in tumor progression, particularly in KRAS-mutated lung adenocarcinomas
metastatic cancer cells have elevated rate of cell injury and they rely on the S100A11-ANXA2 (zeige ANXA2 Proteine) complex to enable cell membrane repair. S100A11 in a complex with Annexin A2 (zeige ANXA2 Proteine) helps reseal the plasma membrane.
All three markers correlated significantly with regional lymph node metastasis: FXYD3 (zeige FXYD3 Proteine) (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (zeige GSTM3 Proteine) (p = 0.0173) in colon cancer lymphatic metastasis.
The EGFRvIII-STAT3 (zeige STAT3 Proteine) pathway promotes cell migration and invasion by upregulating S100A11 in hepatocellular carcinoma.
This work focused on S100A11, a dimeric EF-hand protein (zeige CETN1 Proteine) with two hydrophobic target binding sites. An annexin peptide (Ax) served as the target. Target binding is allosterically controlled by Ca(2 (zeige CA2 Proteine)+) over a distance of approximately 26 A. Ca(2 (zeige CA2 Proteine)+) promotes formation of a [Ca4 (zeige CA4 Proteine) S100 Ax2] complex, where the Ax peptides are accommodated between helices III/IV and III'/IV'.
Studies show that monomeric S100B (zeige S100B Proteine) and S100A11 proteins are alpha-helical and retain a significant amount of tertiary structure.
Endometrial S100A11 is a crucial intermediator in EGF (zeige EGF Proteine)-stimulated embryo adhesion, endometrium receptivity, and immunotolerance via affecting Ca2 (zeige CA2 Proteine)+ uptake and release from intracellular Ca2 (zeige CA2 Proteine)+ stores.
S100A11 is the mouse counterpart of Xenopus dicalcin that suppresses the fertilization process through its action on cumulus cells, and thereby plays a key role in fertilization success in the mouse.
Following transformation by transglutaminase 2 (zeige TGM2 Proteine), S100A11 acquires the capacity to signal through the p38 MAP kinase (zeige MAPK14 Proteine) pathway, accelerate chondrocyte hypertrophy, and couple inflammation with chondrocyte activation to promote progression of osteoarthritis.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
, S100 calcium-binding protein A11 (calgizzarin)
, metastatic lymph node gene 70 protein
, protein S100-A11
, protein S100-C
, S100 calcium-binding protein A11
, S100 calcium binding protein A11 (calizzarin)
, S100C protein
, S100 calcium binding protein A11 (calgizzarin)
, S100 calcium binding protein A14
, endothelial monocyte activating polypeptide 1
, endothelial monocyte-activating polypeptide