anti-S100 Calcium Binding Protein A11 (S100A11) Antikörper

Human S100 Calcium Binding Protein A11 (S100A11) Interaktionspartner

1. findings revealed that S100A11 and TGF-beta1/SMAD4 signaling pathway were related but mutually independent in regulating PANC-1 cells proliferation and apoptosis.

2. Our present study indicated that S100A11 promotes EMT through accumulation of TGF-beta1 expression, and TGF-beta1-induced upregulation of p-SMAD2 and 3.

3. Results show that S100A11 expression is up-regulated by BC200 through stabilizing its mRNA and that S100A11 critically mediates the ability of BC200 RNA to induce cancer cell migration and invasion.

4. identified as a new regulator of Aldo-induced collagen production in human cardiac fibroblasts.

5. Furthermore, we identify flotillin-1 (FLOT1) and histone H1 as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.

6. In patients with rheumatoid arthritis, S100A11 is up-regulated and is associated with inflammation and disease activity.

7. S100A11 overexpression correlates with an aggressive malignant phenotype and may constitute a novel prognostic factor for HGSC

8. S100A11 is involved in homologous recombination by regulating the appearance of RAD51 in double strand break repair sites.

9. we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma.

10. higher S100A11 expression was associated with statistically significant decrease in disease-free survival in clear cell renal cell carcinoma

11. the up-regulation of S100A11 plays a role in tumor progression, particularly in KRAS-mutated lung adenocarcinomas

12. metastatic cancer cells have elevated rate of cell injury and they rely on the S100A11-ANXA2 complex to enable cell membrane repair. S100A11 in a complex with Annexin A2 helps reseal the plasma membrane.

13. All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis.

14. The EGFRvIII-STAT3 pathway promotes cell migration and invasion by upregulating S100A11 in hepatocellular carcinoma.

15. Proteomic data suggest a limited protein set is involved in SET- (template activating factor-I-) mediated cytotoxicity of TCE (trichloroethylene) in hepatocytes; this set includes CFL1 (cofilin 1), PRDX2 (peroxiredoxin 2), and S100-A11 (calgizzarin).

16. Our data indicate that S100A11 overexpression exerts a protumoral functional role in papillary thyroid carcinoma pathogenesis.

17. Data suggest that S100A11 is involved in maintenance of p21-CIP1 (cyclin-dependent kinase inhibitor 1A) protein stability (up-regulation; down-regulation) and appears to function as inhibitor of apoptosis in keratinocytes.

18. the structure of human calcium-bound S100A11.

19. Endometrial S100A11 is a crucial intermediator in EGF-stimulated embryo adhesion, endometrium receptivity, and immunotolerance via affecting Ca2+ uptake and release from intracellular Ca2+ stores.

20. Using transcriptional signatures of blood samples,identified S100A11 as a potential diagnostic marker of infective endocarditis, and AQP9 as a potential prognostic factor.

Rabbit S100 Calcium Binding Protein A11 (S100A11) Interaktionspartner

1. This work focused on S100A11, a dimeric EF-hand protein with two hydrophobic target binding sites. An annexin peptide (Ax) served as the target. Target binding is allosterically controlled by Ca(2+) over a distance of approximately 26 A. Ca(2+) promotes formation of a [Ca4 S100 Ax2] complex, where the Ax peptides are accommodated between helices III/IV and III'/IV'.

2. Studies show that monomeric S100B and S100A11 proteins are alpha-helical and retain a significant amount of tertiary structure.

Mouse (Murine) S100 Calcium Binding Protein A11 (S100A11) Interaktionspartner

1. Endometrial S100A11 is a crucial intermediator in EGF-stimulated embryo adhesion, endometrium receptivity, and immunotolerance via affecting Ca2+ uptake and release from intracellular Ca2+ stores.

2. S100A11 is the mouse counterpart of Xenopus dicalcin that suppresses the fertilization process through its action on cumulus cells, and thereby plays a key role in fertilization success in the mouse.

3. Following transformation by transglutaminase 2, S100A11 acquires the capacity to signal through the p38 MAP kinase pathway, accelerate chondrocyte hypertrophy, and couple inflammation with chondrocyte activation to promote progression of osteoarthritis.