Runt-Related Transcription Factor 1 Proteine (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters.

alle Proteine anzeigen Gen GeneID UniProt
Maus RUNX1 RUNX1 12394 Q03347
Human RUNX1 RUNX1 861 Q01196
Ratte RUNX1 RUNX1 50662 Q63046
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Top RUNX1 Proteine auf

Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

Am meisten referenzierte RUNX1 Proteine

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

Weitere Proteine zu Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartnern

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Results suggest that AML1/ETO (zeige RUNX1T1 Proteine) expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC (zeige FUT1 Proteine) emergence.

  3. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (zeige NFE2 Proteine) and either RUNX1, FLI1 (zeige FLI1 Proteine) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  4. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT (zeige CBFA2T2 Proteine)) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  5. CDK6 (zeige CDK6 Proteine) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  6. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  7. These results suggest that RUNX1 may be an essential modulator in BMP9 (zeige GDF2 Proteine)- induced osteogenic differentiation of mesenchymal stem cells.

  8. Loss of Runx1 and Runx2 (zeige RUNX2 Proteine) inhibits prostate cell motility.

  9. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

  10. High RUNX1 expression is associated with lymphoma.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our findings show the profound impact of RUNX1 allele dosage on gene expression profile and glucocorticoid sensitivity in AML, thereby opening opportunities for preclinical testing which may lead to drug repurposing and improved disease characterization.

  2. This study established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34 (zeige CD34 Proteine)+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated.

  3. Genome-engineered hPSCs expressing ETV6 (zeige ETV6 Proteine)-RUNX1 from the endogenous ETV6 (zeige ETV6 Proteine) locus show expansion of the CD19 (zeige CD19 Proteine)(-)IL-7R(+) compartment

  4. our study demonstrated that specific bone marrow abnormalities and acquired genetic alterations may be harbingers of progression to hematological malignancies in patients with familial platelet disorder with germline RUNX1 mutation.

  5. These studies provide the first evidence in patients with a RUNX1 mutation for a defect in AH (lysosomal) secretion, and for a global defect in secretion involving all three types of platelet granules that is unrelated to a granule content deficiency. They highlight the pleiotropic effects and multiple platelet defects associated with RUNX1 mutations.

  6. Younger mRUNX1 AML patients treated with intensive chemotherapy experienced inferior treatment outcomes. In older patients with AML treated with hypomethylating agent (HMA) therapy, response and survival was independent of RUNX1 status. Older mRUNX1 patients with prior myelodysplastic syndrome or myeloproliferative neoplasms (MDS (zeige PAFAH1B1 Proteine)/MPN (zeige PRSS27 Proteine)) had particularly dismal outcome

  7. Data indicate miR (zeige MLXIP Proteine)-29b-1 as a regulator of the AML1-ETO (zeige RUNX1T1 Proteine) protein (RUNX1-RUNX1T1 (zeige RUNX1T1 Proteine)), and that miR (zeige MLXIP Proteine)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  8. EBPA and RUNX1 are expressed at higher levels in patients with acute myeloid leukemia (zeige BCL11A Proteine) in comparison to healthy subjects

  9. The first characterization of this CASC15 in RUNX1-translocated leukemia.

  10. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO (zeige RUNX1T1 Proteine)/THAP10 (zeige THAP10 Proteine)/miR (zeige MLXIP Proteine)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (zeige THAP10 Proteine) predicts a poor clinical outcome and represents a novel therapeutic target.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF Proteine) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 Proteine) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 Proteine), or cohesin subunit Smc3 (zeige SMC3 Proteine), fail to express runx3 (zeige RUNX3 Proteine) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 Proteine) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Überblick

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • uncharacterized LOC473981 (LOC473981)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (runx1)
  • runt related transcription factor 1 L homeolog (runx1.L)
  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 Protein
  • aml Protein
  • aml-1 Protein
  • Aml1 Protein
  • aml1-evi-1 Protein
  • amlcr1 Protein
  • cbfa2 Protein
  • evi-1 Protein
  • Pebp2a2 Protein
  • pebp2ab Protein
  • Pebpa2b Protein
  • Runx-1 Protein
  • runx1 Protein
  • runxa Protein
  • XAML Protein
  • Xaml1 Protein

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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