Runt-Related Transcription Factor 1 Proteine (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Antikörper (285) und RUNX1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 Proteine auf

Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

RUNX1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte RUNX1 Proteine

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

Weitere Proteine zu Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartnern

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF (zeige ZBTB16 Proteine).

  2. Study reveals a previously unrecognized synergism between ETV6 (zeige ETV6 Proteine)/RUNX1 and BCL2 (zeige BCL2 Proteine) impacting on malignant disease and autoimmunity.

  3. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

  4. The findings suggest that the absence of uPA (zeige PLAU Proteine) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  5. Flt3 and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development.

  6. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (zeige AQP5 Proteine) protein of the acinar cells in the SMG (zeige SNRPG Proteine) in order to allow for the proper secretion of saliva (zeige RAG1AP1 Proteine)

  7. High RUNX1 expression is associated with skin squamous cell carcinoma.

  8. deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 Proteine)- and NOTCH1 (zeige NOTCH1 Proteine)-regulated genes, including the MYB (zeige MYB Proteine) and MYC (zeige MYC Proteine) oncogenes, respectively.

  9. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  10. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. The here presented transcriptomic subgroup-based approach unified the gene expression profiles of RUNX1-CBFA2T3 (zeige CBFA2T3 Proteine) and RUNX1-RUNX1T1 (zeige RUNX1T1 Proteine) acute myeloid leukemia (zeige BCL11A Proteine).

  2. Platelet CD34 (zeige CD34 Proteine) expression and alpha/delta-granule abnormalities in GFI1B (zeige GFI1B Proteine)- and RUNX1-related familial bleeding disorders.

  3. We observed a strong correlation between EVI1 (zeige MECOM Proteine) and alpha1, 6-fucosyltransferase (FUT8 (zeige FUT8 Proteine)) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.

  4. A novel function of RUNX1 and offer an explanation for the link between RUNX1 mutations and chemotherapy and radiation resistance. Moreover, these data suggest that pharmacologic modulation of RUNX1 might be an attractive new approach to treat hematologic malignancies.

  5. high EVI1 (zeige MECOM Proteine) expression might predict high risk of relapse in AML patients undergoing myeloablative allo-HSCT in CR1.

  6. Hypermethylation of the CTNNA1 (zeige CTNNA1 Proteine) promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (zeige ASXL1 Proteine) and RUNX1 mutations.

  7. Three siblings with germline causative RUNX1 variant, developed acute myelomonocytic leukemia and acquired variants within the JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) pathway, specifically targeting JAK2 (zeige JAK2 Proteine) and SH2B3 (zeige SH2B3 Proteine).

  8. These findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in cytogenetically normal acute myeloid leukemia (zeige BCL11A Proteine)

  9. 3 di ff erent heterozygous mutations segregated with thrombocytopenia in 3 families: one missense (c.578T > A/p.Ile193Asn) variant a ff ecting a well conserved residue of the runt-homologous domain, 2 nucleotide substitutions of the canonical "gt" dinucleotide in the donor splice sites of intron 4, (c.351 1 1G > A) and intron 8 (c.967 1 2_5del), and 2 alternative spliced products affecting the transactivation domain.

  10. Here, we report the first identification of H3(K27M) and H3(K27I) mutations in patients with AML. We find that these lesions are major determinants of reduced H3K27me2/3 in these patients and that they are associated with common aberrations in the RUNX1 gene.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF Proteine) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 Proteine) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 Proteine), or cohesin subunit Smc3 (zeige SMC3 Proteine), fail to express runx3 (zeige RUNX3 Proteine) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 Proteine) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Überblick

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • uncharacterized LOC473981 (LOC473981)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (runx1)
  • runt related transcription factor 1 L homeolog (runx1.L)
  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 Protein
  • aml Protein
  • aml-1 Protein
  • Aml1 Protein
  • aml1-evi-1 Protein
  • amlcr1 Protein
  • cbfa2 Protein
  • evi-1 Protein
  • Pebp2a2 Protein
  • pebp2ab Protein
  • Pebpa2b Protein
  • Runx-1 Protein
  • runx1 Protein
  • runxa Protein
  • XAML Protein
  • Xaml1 Protein

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Ausgewählte Anbieter für RUNX1 Proteine (RUNX1)
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