Runt-Related Transcription Factor 1 Proteine (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Antikörper (314) und RUNX1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human RUNX1 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

RUNX1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte RUNX1 Proteine

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

Weitere Proteine zu Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartnern

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. RUNX1 promoted TGF-beta (zeige TGFB1 Proteine)-induced partial EMT (zeige ITK Proteine) by increasing transcription of the PI3K subunit p110delta, which mediated Akt (zeige AKT1 Proteine) activation.

  2. The promoter regions of Runx1 is targets of STAT4 (zeige STAT4 Proteine) and that STAT4 (zeige STAT4 Proteine) binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

  3. Results suggest that AML1/ETO (zeige RUNX1T1 Proteine) expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  4. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC (zeige FUT1 Proteine) emergence.

  5. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (zeige NFE2 Proteine) and either RUNX1, FLI1 (zeige FLI1 Proteine) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  6. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT (zeige CBFA2T2 Proteine)) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  7. CDK6 (zeige CDK6 Proteine) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  8. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  9. These results suggest that RUNX1 may be an essential modulator in BMP9 (zeige GDF2 Proteine)- induced osteogenic differentiation of mesenchymal stem cells.

  10. Loss of Runx1 and Runx2 (zeige RUNX2 Proteine) inhibits prostate cell motility.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-144 mimics can inhibit the proliferation and migration of ovarian cancer cells though regulating the expression of RUNX1.

  2. The effect of FENDRR on cell proliferation, apoptosis and invasion and migration ability in protate cancer cells was suppressed by silence of RUNX1.

  3. KSRP (zeige KHSRP Proteine), miR (zeige MLXIP Proteine)-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation.

  4. PKM2 (zeige PKM Proteine) as a novel target of RUNX1-ETO (zeige RUNX1T1 Proteine) and is specifically downregulated in RUNX1-ETO (zeige RUNX1T1 Proteine) positive AML patients, indicating that PKM2 (zeige PKM Proteine) level might have a diagnostic potential in RUNX1-ETO (zeige RUNX1T1 Proteine) associated AML.

  5. specific type of RUNX1 mutation did not affect its association pattern with trisomy 21

  6. High RUNX1 expression is associated with prostatic cancer.

  7. RUNX1 Mutation is associated with acute myeloid leukemia (zeige BCL11A Proteine).

  8. The specific association of ZBTB7A (zeige ZBTB7A Proteine) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (zeige ZBTB7A Proteine) and the RUNX1/RUNX1T1 (zeige RUNX1T1 Proteine) fusion protein has been reported.

  9. miR (zeige MLXIP Proteine)-216a-3p can promote gastric cancer cell proliferation, migration, and invasion via targeting RUNX1 and activating the NF-kappaB (zeige NFKB1 Proteine) signaling pathway

  10. the t(5;21)(p15 (zeige CDKN2B Proteine);q22) translocation could be identified only when what had seemed like a del(21)(qq) in G-banded preparations was examined using FISH and RNA-sequencing directed at finding out what lay behind the 21q-.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF Proteine) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 Proteine) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 Proteine), or cohesin subunit Smc3 (zeige SMC3 Proteine), fail to express runx3 (zeige RUNX3 Proteine) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 Proteine) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Überblick

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • uncharacterized LOC473981 (LOC473981)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (runx1)
  • runt related transcription factor 1 L homeolog (runx1.L)
  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 Protein
  • aml Protein
  • aml-1 Protein
  • Aml1 Protein
  • aml1-evi-1 Protein
  • amlcr1 Protein
  • cbfa2 Protein
  • evi-1 Protein
  • Pebp2a2 Protein
  • pebp2ab Protein
  • Pebpa2b Protein
  • Runx-1 Protein
  • runx1 Protein
  • runxa Protein
  • XAML Protein
  • Xaml1 Protein

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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