Runt-Related Transcription Factor 1 (RUNX1) ELISA Kits

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Antikörper (285) und RUNX1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Ratte 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Weitere ELISA Kits für RUNX1 Interaktionspartner

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

  2. Study reveals a previously unrecognized synergism between ETV6 (zeige ETV6 ELISA Kits)/RUNX1 and BCL2 (zeige BCL2 ELISA Kits) impacting on malignant disease and autoimmunity.

  3. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

  4. The findings suggest that the absence of uPA (zeige PLAU ELISA Kits) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  5. Flt3 and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development.

  6. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (zeige AQP5 ELISA Kits) protein of the acinar cells in the SMG (zeige SNRPG ELISA Kits) in order to allow for the proper secretion of saliva (zeige RAG1AP1 ELISA Kits)

  7. High RUNX1 expression is associated with skin squamous cell carcinoma.

  8. deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 ELISA Kits)- and NOTCH1 (zeige NOTCH1 ELISA Kits)-regulated genes, including the MYB (zeige MYB ELISA Kits) and MYC (zeige MYC ELISA Kits) oncogenes, respectively.

  9. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  10. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. We observed a strong correlation between EVI1 (zeige MECOM ELISA Kits) and alpha1, 6-fucosyltransferase (FUT8 (zeige FUT8 ELISA Kits)) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.

  2. A novel function of RUNX1 and offer an explanation for the link between RUNX1 mutations and chemotherapy and radiation resistance. Moreover, these data suggest that pharmacologic modulation of RUNX1 might be an attractive new approach to treat hematologic malignancies.

  3. high EVI1 (zeige MECOM ELISA Kits) expression might predict high risk of relapse in AML patients undergoing myeloablative allo-HSCT in CR1 (zeige CR1 ELISA Kits).

  4. Hypermethylation of the CTNNA1 (zeige CTNNA1 ELISA Kits) promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (zeige ASXL1 ELISA Kits) and RUNX1 mutations.

  5. Three siblings with germline causative RUNX1 variant, developed acute myelomonocytic leukemia and acquired variants within the JAK (zeige JAK3 ELISA Kits)-STAT (zeige STAT1 ELISA Kits) pathway, specifically targeting JAK2 (zeige JAK2 ELISA Kits) and SH2B3 (zeige SH2B3 ELISA Kits).

  6. These findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in cytogenetically normal acute myeloid leukemia (zeige BCL11A ELISA Kits)

  7. 3 di ff erent heterozygous mutations segregated with thrombocytopenia in 3 families: one missense (c.578T > A/p.Ile193Asn) variant a ff ecting a well conserved residue of the runt-homologous domain, 2 nucleotide substitutions of the canonical "gt" dinucleotide in the donor splice sites of intron 4, (c.351 1 1G > A) and intron 8 (c.967 1 2_5del), and 2 alternative spliced products affecting the transactivation domain.

  8. Here, we report the first identification of H3(K27M) and H3(K27I) mutations in patients with AML. We find that these lesions are major determinants of reduced H3K27me2/3 in these patients and that they are associated with common aberrations in the RUNX1 gene.

  9. NPM1 (zeige NPM1 ELISA Kits) mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia (zeige BCL11A ELISA Kits) lacking recurrent cytogenetic abnormalities

  10. phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF ELISA Kits) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 ELISA Kits) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 ELISA Kits), or cohesin subunit Smc3 (zeige SMC3 ELISA Kits), fail to express runx3 (zeige RUNX3 ELISA Kits) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 ELISA Kits) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen-Profil

Beschreibung des Gens

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • uncharacterized LOC473981 (LOC473981) Antikörper
  • runt-related transcription factor (runt) Antikörper
  • runt related transcription factor 1 (Runx1) Antikörper
  • runt related transcription factor 1 (RUNX1) Antikörper
  • runt-related transcription factor 1 (runx1) Antikörper
  • runt related transcription factor 1 L homeolog (runx1.L) Antikörper
  • runt-related transcription factor 1 (RUNX1) Antikörper
  • runt-related transcription factor 1 (Runx1) Antikörper
  • AI462102 Antikörper
  • aml Antikörper
  • aml-1 Antikörper
  • Aml1 Antikörper
  • aml1-evi-1 Antikörper
  • amlcr1 Antikörper
  • cbfa2 Antikörper
  • evi-1 Antikörper
  • Pebp2a2 Antikörper
  • pebp2ab Antikörper
  • Pebpa2b Antikörper
  • Runx-1 Antikörper
  • runx1 Antikörper
  • runxa Antikörper
  • XAML Antikörper
  • Xaml1 Antikörper

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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