Ring Finger Protein 111 Proteine (RNF111)

The protein encoded by RNF111 is a nuclear RING-domain containing E3 ubiquitin ligase. Zusätzlich bieten wir Ihnen RNF111 Antikörper (36) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RNF111 54778 Q6ZNA4
RNF111 93836 Q99ML9
Ratte RNF111 RNF111 300813  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

RNF111 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu Ring Finger Protein 111 (RNF111) Interaktionspartnern

Human Ring Finger Protein 111 (RNF111) Interaktionspartner

  1. Results indicate a tumor-suppressive role of the ring finger protein 111 (Arkadia)-epithelial splicing regulatory protein 2 (ESRP2 (zeige ESRP2 Proteine)) axis in clear-cell renal cell carcinoma (zeige MOK Proteine) (ccRCC).

  2. These data show that the position occupied by W972 within wild-type Arkadia is critical for the function of its RING domain and that it depends on the nature of the residue at this position.

  3. Results suggest that -459CpG methylation in Sp1 (zeige PSG1 Proteine)-binding site of RNF111 promoter transcriptionally decreases RNF111 expression, which inhibits TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling associated invasion in NSCLC cells.

  4. Study reports that the monomeric RING domains from the human E3 ligases Arkadia and Ark2C bind directly to free ubiquitin with an affinity comparable to that of other dedicated ubiquitin-binding domains.

  5. These data suggest that RNF111, together with the CRL4(DDB2 (zeige DDB2 Proteine)) ubiquitin ligase complex, is responsible for sequential XPC (zeige XPC Proteine) ubiquitylation, which regulates the recruitment and release of XPC (zeige XPC Proteine) and is crucial for efficient progression of the NER (zeige NR1H2 Proteine) reaction.

  6. Arkadia can both promote and inhibit gene expression, indicating that Arkadia's activity in transcriptional control may depend on the epigenetic context, defined by Polycomb (zeige CBX2 Proteine) repressive complexes and DNA methylation (zeige HELLS Proteine).

  7. Our findings establish RNF111 as a new STUbL that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response.

  8. findings indicate that Arkadia is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis

  9. Arkadia is involved in arsenic-induced degradation of polysumoylated PML (zeige PML Proteine) protein.

  10. RNF111-dependent neddylation activates DNA damage-induced ubiquitination

Mouse (Murine) Ring Finger Protein 111 (RNF111) Interaktionspartner

  1. Arkadia, but not the C937A (CA) mutant lacking E3 ubiquitin-ligase (zeige MUL1 Proteine) activity, induced ubiquitylation and proteasome-dependent degradation of Smad6 (zeige SMAD6 Proteine).

  2. Arkadia enhances transforming growth factor-beta signaling responses and supports its tumor-suppressing properties in colorectal cancer.

  3. RB1CC1 thus appears to play a unique role as a modulator of TGF-beta (zeige TGFB1 Proteine) signaling by restricting substrate specificity of Arkadia.

  4. Trps1 haploinsufficiency enhances TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.

  5. findings show that Arkadia regulates the levels of expression of c-Ski (zeige SKI Proteine) protein (zeige SKIL Proteine) in cell-type-dependent fashion, and exhibits a tumour suppressor function by inhibiting tumour cell growth

  6. Axin (zeige AXIN1 Proteine) and Arkadia cooperate with each other in promoting Smad7 (zeige SMAD7 Proteine) ubiquitination.

  7. Arkadia, a nuclear RING-domain E3 ubiquitin ligase (zeige MUL1 Proteine), is essential for a subset of Nodal functions in the embryo

  8. Arkadia induces degradation of SnoN (zeige SKIL Proteine) and c-Ski (zeige SKI Proteine) in addition to Smad7 (zeige SMAD7 Proteine).

  9. These results suggest that Arkadia targets Ski (zeige SKI Proteine)-bound, inactive phospho-Smad2 (zeige SMAD2 Proteine)/3 to regulate positively Myostatin (zeige MSTN Proteine)/TGF-beta (zeige TGFB1 Proteine) signaling.

  10. This work presents an efficient method for expression in E. coli and purification of recombinant Arkadia RING finger (zeige PCGF1 Proteine) domain as a soluble protein.

RNF111 Protein Überblick

Protein Überblick

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit RNF111

  • ring finger protein 111 (RNF111)
  • ring finger 111 (Rnf111)
  • ring finger protein 111 (Rnf111)
  • ring finger protein 111 (rnf111-b)
  • ring finger protein 111 (rnf111)
  • ark Protein
  • Arkadia Protein
  • MGC81253 Protein
  • MGC146379 Protein
  • rnf111 Protein

Bezeichner auf Proteinebene für RNF111

Arkadia , E3 ubiquitin-protein ligase Arkadia , RING finger protein 111 , ring finger 111 , arkadia , ring finger protein 111 , E3 ubiquitin-protein ligase arkadia-B , RING finger protein 111-B , e3 ubiquitin-protein ligase Arkadia-like

54778 Homo sapiens
540353 Bos taurus
93836 Mus musculus
300813 Rattus norvegicus
374021 Gallus gallus
453477 Pan troglodytes
478323 Canis lupus familiaris
701953 Macaca mulatta
779113 Xenopus laevis
780266 Xenopus (Silurana) tropicalis
100054463 Equus caballus
100222518 Taeniopygia guttata
100357930 Oryctolagus cuniculus
100475090 Ailuropoda melanoleuca
100543062 Meleagris gallopavo
100555431 Anolis carolinensis
100579843 Nomascus leucogenys
100155446 Sus scrofa
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