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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
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Low RPL5 expression is associated with cancer.
Ribosomal proteins L11 (zeige RPL11 Proteine) and L5 activate TAp73 (zeige TP73 Proteine) by overcoming MDM2 (zeige MDM2 Proteine) inhibition.
RPL5 mutation is associated with Diamond Blackfan Anemia.
Findings uncover a mechanism by which RPL5 and RPL11 (zeige RPL11 Proteine) can co-operatively suppress c-Myc (zeige MYC Proteine) expression, allowing a tightly controlled ribosome biogenesis in cells.
Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation.
High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia.
Oncogenic splicing factor (zeige SLU7 Proteine) SRSF1 (zeige SRSF1 Proteine) stabilizes the tumor suppressor protein p53 (zeige TP53 Proteine) via RPL5, inducing cell senescence.
Mutations affect the ribosomal proteins RPL5 and RPL10 (zeige RPL10 Proteine) in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias.
disrupted nucleoli may provide a platform for L5- and L11 (zeige RPL11 Proteine)-dependent p53 (zeige TP53 Proteine) activation, implying a role for the nucleolus in p53 (zeige TP53 Proteine) activation by ribosomal biogenesis stress
Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A (zeige RPL35A Proteine) deletion, 3 with RPS17 (zeige RPS17 Proteine) deletions, and 1 with an RPS19 (zeige RPS19 Proteine) deletion.
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2 (zeige MDM2 Proteine)/p53 (zeige TP53 Proteine) axis which is important in normal hematopoiesis.
There was a significant delay in the G2/M phase in Rpl5 mutant cells, unaffected by p53 (zeige TP53 Proteine) knockdown.
RpL5, located in the centric heterochromatin of chromosome 2, was analyzed genetically.
eclipse might be a novel ribosome associated protein interacting with dRPL5
These results therefore provide a comprehensive basis for the study of molecular pathogenesis of RPL5-mediated Diamond-Blackfan anemia and other ribosomopathies.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L5
, enhancer on chromosome 2, complementation group d
, ribosomal protein L5
, yippee interacting protein 6
, 60S ribosomal protein L5-B
, 60S ribosomal protein L5-like protein
, ribosomal protein L5, like